by Dennis Thompson A new treatment appears to reduce food allergies in children and teens, according to interim clinical trial results. A lab-made monoclonal antibody called omalizumab (Xolair) significantly increased the amounts of common foods that children could eat without sparking an allergic reaction, the U.S. National Institute of Allergy and Infectious Diseases (NIAID) reported....
by Public Library of Science Humans mount convergent H1N1-H3N2 neutralizing antibody responses to influenza virus. Panels are derived from structures reported by Simmons et al., (PDB 7TRH, 7RRI and 3UBE by Xu et al., for the model of receptor engagement). Credit: Kevin McCarthy (CC-BY 4.0, creativecommons.org/licenses/by/4.0/) Researchers have identified a previously unrecognized class of antibodies—immune system...
SAN DIEGO — CD19-directed chimeric antigen receptor (CAR) T-cell therapy, which has transformed the treatment landscape for B-cell malignancies, is now showing great promise in at least three distinct autoantibody-dependent autoimmune diseases. A single infusion of autologous CD19-directed CAR T-cell therapy led to persistent, drug-free remission in 15 patients with life-threatening systemic lupus erythematosus, idiopathic...
by Ragon Institute of MGH, MIT and Harvard 3D rendering of a B cell. Credit: Blausen.com staff (2014). “Medical gallery of Blausen Medical 2014”. WikiJournal of Medicine 1 (2). DOI:10.15347/wjm/2014.010. ISSN 2002-4436. CC BY-SA 4.0 B cell deficiency is a common condition that can result either from immunosuppressant drugs used to treat autoimmune disease or...
by Delthia Ricks , Medical Xpress N6F11 suppresses the growth of human PDAC. (A) PANC1 cells were pretreated with DMSO or N6F11 (5 µM) for 12 hours. (B) MiaPACA2 cells were pretreated with DMSO or N6F11 (5 µM) for 12 hours. (C) Effects of N6F11 on the growth of 3D PANC1 tumor spheroids for increasing...
by SAGE Publications A medical assistant prepares a dose of a COVID-19 vaccine to be administered to a patient. Credit: Public domain image courtesy of Lisa Ferdinando, U.S. Department of Defense The risk of death from COVID-19 decreases significantly after vaccination but this protection diminishes after six months, providing evidence for continued booster doses, a new...
by Ludwig Maximilian University of Munich The ASC speck is a central component of the NLRP3 inflammasome. Credit: iScience (2023). DOI: 10.1016/j.isci.2023.108382 A central component of the human immune system, the NLRP3 inflammasome plays an important role in fighting off infections. However, its chronic activation is also implicated in a variety of common diseases, such as...
University of Cambridge Researchers have discovered that misreading of therapeutic mRNAs by the cell’s decoding machinery can cause an unintended immune response in the body. They have identified the sequence within the mRNA that causes this to occur and found a way to prevent ‘off-target’ immune responses to enable the safer design of future mRNA...
Whether it provides lasting protection remains to be seen by Katherine Kahn, Staff Writer, MedPage Today December 13, 2023A computer rendering of RSV viruses in the lungs. Moderna’s mRNA-based RSV vaccine was effective at preventing RSV-associated lower respiratory tract disease in adults ages 60 and older, according to results of the randomized ConquerRSVopens in a...
By CodeBlue | 14 December 2023 WHO recommends monovalent XBB.1.5 Covid-19 vaccines across different platforms against circulating variants. Malaysia’s MOH has yet to issue an updated Covid-19 vaccine advisory for 2024 or to announce if the monovalent XBB.1.5 vaccine will be procured. Vaccination of a senior male patient at a hospital. Photo by aslysun/ shutterstock.com....
