October 1, 2024 by Texas Biomedical Research Institute Researchers compare the impacts of cART by itself versus cART plus the IDO inhibitor in lung tissue of nonhuman primates with both TB and SIV. Left: Following just cART, significantly more IDO is detected in pink. Right: With the IDO inhibitor and cART, immune cells recruited to...
Category: <span>Immunology</span>
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Researchers discover mechanism driving immune perturbations after severe infections
September 30, 2024 by Taylor Barnes, Baylor College of Medicine Researchers at Baylor College of Medicine and collaborating institutions have discovered a mechanism that drives the long-term decline in immune response that is observed after tuberculosis (TB) has been successfully treated. Their findings, published in the Proceedings of the National Academy of Sciences, suggest a...
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Cellular power-up: Stem cells provide T cells a lifeline as cancer champions
October 1, 2024 by University of Los Andes Experimental workflow of MitoT to native and CAR engineered T cells. Credit: Journal of Translational Medicine (2024). DOI: 10.1186/s12967-024-05627-4In a pioneering study that bridges the gap between science fiction and reality, researchers have unveiled an innovative method to enhance T and CAR-T cells—our body’s natural and engineered...
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Unique immune response in lupus paves the way for new treatments
Graphical abstract. Credit: Immunity (2024). DOI: 10.1016/j.immuni.2024.09.004 Immune cells called monocytes produce a key inflammatory protein called interleukin-1 beta (IL-1β) through an unconventional pathway in patients with systemic lupus erythematosus, commonly referred to as lupus, according to a new study by Weill Cornell Medicine investigators. The findings, published in Immunity, could lead to new treatments targeting IL-1β to better manage...
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Novel antibodies against Klebsiella pneumoniae identified
September 26, 2024 by University Medical Center Utrecht Department of Medical Microbiology at UMC Utrecht. Credit: University Medical Center UtrechtResearch at UMC Utrecht has identified 29 novel antibodies against the bacterium Klebsiella pneumoniae, an important cause of drug-resistant infections. Using genetic and functional approaches, the researchers also managed to unravel how these antibodies interact with...
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Scientists develop CAR-T cells to target glioblastoma while sparing healthy tissue
September 26, 2024 by University of Geneva Immunofluorescence staining of a representative human glioblastoma tissue section. In red, the PTPRZ1 markers, and in blue, the cell nuclei. (scale bar: 400 μm). Credit: Denis Migliorini – UNIGE/HUGScientists at UNIGE and HUG have developed CAR-T cells capable of targeting malignant gliomas while preserving healthy tissue. Glioblastoma is...
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Unexpected immune response may hold key to long-term cancer remission
September 26, 2024 by Celia Luterbacher, Ecole Polytechnique Federale de Lausanne From left to right: Co-authors Weilin Li, Tom Enbar, Li Tang, and Lucia Bonati. Credit: Alain HerzogResults from a preclinical study in mice led by EPFL, and a collaborative clinical study in patients show that the type 2 immune response—associated with parasitic infection and...
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An integral T cell pathway has implications for understanding sex-based immune response
T cells from a healthy human female donor were stimulated with antibodies anti-CD3 and anti-CD28 for 48 hours. On the left are cells treated with a control and on the right are cells treated with a chemical inhibitor of NF-κB. The pink stain shows Xist RNA, a long noncoding RNA molecule that initiates and maintains...
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Preclinical studies suggest a drug-free nasal spray could ward off respiratory infections
September 25, 2024 by Brigham and Women’s Hospital Pathogens inhaled along with respiratory droplets enter through the nasal lining, causing respiratory infections. Brigham researchers have developed a pathogen capture and neutralizing spray (PCANS), which coats the nasal cavity, capturing large respiratory droplets and serving as a physical barrier against a broad spectrum of viruses and...
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Combination treatment improves response to immunotherapy for lung cancer, mouse study shows
September 25, 2024 by The Francis Crick Institute Credit: Pixabay/CC0 Public DomainResearchers at the Francis Crick Institute, in collaboration with Revolution Medicines, have tested a combination of treatments in mice with lung cancer and shown that these allow immunotherapies to target non-responsive tumors. Their findings show that targeting tumors in different ways simultaneously might increase...