September 23, 2024 by Jan Grabowski, TWINCORE – Zentrum für Experimentelle und Klinische Infektionsforschung TLR8 is expressed in monocytes and cDCs but not pDCs of patients with systemic sclerosis (SSc). Credit: Arthritis & Rheumatology (2024). DOI: 10.1002/art.42964Systemic sclerosis is an autoimmune disease that primarily causes inflammation of the skin, as well as internal organs such...
Category: <span>Immunology</span>
Researchers ‘turbocharge’ vaccine delivery by jolting ‘bystander’ immune cells into action in animal models
September 23, 2024 by Monash University Credit: Immunity (2024). DOI: 10.1016/j.immuni.2024.08.017Monash University researchers have developed a new technique to boost the effectiveness of both traditional and mRNA-based vaccines in animal models. Published in Immunity, the study found that adding low doses of a vaccine-specific antibody to a COVID-19 vaccine stimulated the immune system’s B cells,...
Exploring the effect of low sodium concentrations on brain microglial cells
September 18, 2024 by Fujita Health University In a new study, scientists investigated the impact of low sodium concentrations and its rapid correction on nitric oxide production dependent on expression of Nfat5 in microglial cells. Credit: Yoshihisa Sugimura from Fujita Health UniversityLow serum sodium concentrations in the blood are called hyponatremia, a prevalent clinical electrolyte...
Critical immune factor for host defense against MRSA offers potential explanation for unsuccessful vaccine strategies
September 17, 2024 by Amsterdam University Medical Centers A colorized scanning electron micrograph of MRSA. Credit: National Institute of Allergy and Infectious DiseasesStaphylococcus aureus, mostly known from its antibiotic-resistant variant methicillin-resistant Staphylococcus aureus (MRSA), is among the leading causes of both community- and hospital-acquired infections. According to the most recent data, MRSA killed around 120,000...
Research suggests many people already have T cells with the power to fight avian flu
September 17, 2024 by La Jolla Institute for Immunology Credit: CC0 Public DomainResearch led by scientists at La Jolla Institute for Immunology (LJI) suggests that many people already have immune cells on “stand by” to fight the H5N1 virus, also known as highly pathogenic avian influenza. The H5N1 “bird flu” virus emerged in 2022 and...
Monoclonal antibodies offer hope for tackling antimicrobial resistance
News Release 16-Sep-2024 Peer-Reviewed PublicationUniversity of Cambridge Monoclonal antibodies – treatments developed by cloning a cell that makes an antibody – could help provide an answer to the growing problem of antimicrobial resistance, say scientists. A team lead by researchers at the University of Cambridge has developed a monoclonal antibody drug, using a technique involving...
Depemokimab cuts exacerbation rate in eosinophilic asthma
September 11, 2024 by Elana Gotkine For patients with severe asthma with an eosinophilic phenotype, depemokimab reduces the annualized rate of exacerbations, according to a study published online Sept. 9 in the New England Journal of Medicine to coincide with the European Respiratory Society Congress, held from Sept. 7 to 11 in Vienna. David J....
Healthcare workers unprepared for mpox outbreak due to knowledge gaps and vaccine inequity
By Dr. Sanchari Sinha Dutta, Ph.D. Aug 27 2024 Study: International healthcare workers’ experiences and perceptions of the 2022 multi-country mpox outbreak. Image Credit: Corona Borealis Studio / Shutterstock *Important notice: medRxiv publishes preliminary scientific reports that are not peer-reviewed and, therefore, should not be regarded as conclusive, guide clinical practice/health-related behavior, or treated as...
FDA approves updated COVID shots for fall
August 22, 2024 by Ernie Mundell Updated shots you may soon get to shield against COVID-19 infection were approved by the U.S. Food and Drug Administration on Thursday. This year’s approval for the updated mRNA vaccines comes much sooner than happened in 2023, when fall vaccines were authorized on Sept. 11. The latest shots from...
Long-term metastatic melanoma survival dramatically improves on immunotherapy, clinical trial finds
September 15, 2024 by Weill Cornell Medical College Credit: CC0 Public DomainLong-term data from a landmark international trial show about half of patients with metastatic melanoma treated with a combination of immune checkpoint inhibitors survive cancer-free for 10 years or more, according to a new report from Weill Cornell Medicine and Dana-Farber Cancer Center investigators...