Dementia affects 850,000 UK people but this is set to rise to 1 million by 2027 Half a million suffer from the most common form, Alzheimer’s — with no cure But now a number of scientists claim to be on the verge of a major breakthrough Deep within the Andes in a coastal town called...
Category: <span>Medical Education</span>
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Researchers first to unlock key molecular mystery of premature aging syndromes November 27, 2017, Florida State University
New research from Florida State University is beginning to piece together the stubborn puzzle posed by a family of rare and debilitating premature aging disorders. Most of these diseases, called progeroid syndromes, share physiological symptoms characterized by the appearance of accelerated aging, such as skin disorders, loss of hair, skeletal and dental abnormalities and cardiovascular...
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Is a Common Shoulder Surgery Useless?
TUESDAY, Nov. 21, 2017 (HealthDay News) — New research casts doubt on the true effectiveness of a common type of surgery used to ease shoulder pain. A British research team tracked outcomes for patients who underwent “decompression surgery” to treat shoulder impingement — a condition where a shoulder tendon rubs and catches in the joint....
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Primary care physicians cautious about new guidelines for high blood pressure
The lower threshold recommended by the American College of Cardiology and the American Heart Association classifies 46 percent of U.S. adults as having high blood pressure, compared with 32 percent under the previous definition. Primary care faculty at UMass Medical School will continue counseling patients about lifestyle modifications as well as medication to manage...
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How bacteria in the gut influence neurodegenerative disorders
Understanding the role of the microbiome may lead to better treatments for Parkinson’s, Alzheimer’s Humans have roughly as many bacterial cells in their bodies as human cells, and most of those bacteria live in the gut. New research released today reveals links between the gut microbiome — the population of microorganisms living in the gastrointestinal...
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A Primer on Concepts and Applications of Proteomics in Neuroscience
The enormous complexity of the central nervous system has impeded its systemic exploration for decades but powerful “omic” technologies are now pushing forward the frontiers of neuroscience research at an increasing pace. This Primer reviews the most recent progress in mass spectrometry (MS)-based proteomics, focusing on the analysis of whole proteomes, protein-based interactions, and post-translational...
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Cell Biology of Astrocyte-Synapse Interactions
Astrocytes, the most abundant glial cells in the mammalian brain, are critical regulators of brain development and physiology through dynamic and often bidirectional interactions with neuronal synapses. Despite the clear importance of astrocytes for the establishment and maintenance of proper synaptic connectivity, our understanding of their role in brain function is still in its infancy....
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Optogenetic Tools for Subcellular Applications in Neuroscience
Summary The ability to study cellular physiology using photosensitive, genetically encoded molecules has profoundly transformed neuroscience. The modern optogenetic toolbox includes fluorescent sensors to visualize signaling events in living cells and optogenetic actuators enabling manipulation of numerous cellular activities. Most optogenetic tools are not targeted to specific subcellular compartments but are localized with limited discrimination throughout the cell....
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Researchers discover eight new epilepsy genes
Generalized 3 Hz spike and wave discharges in a child with childhood absence epilepsy. Approximately 30 per cent of patients with epilepsy do not respond to anti-epileptic drugs. In these cases, all neurologists can do is attempt to find the right combination of medication through trial and error. A treatment that could target the...
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RefEx, a web tool for a comfortable search of reference data for gene expression analysis
You can search gene expression data by gene name or ID, etc. Tissue-specific genes can be browsed by clicking tissue icons. Currently, there are many public databases available to everyone in the field of life science, but there are many problems when you try to use them, namely you do not know which to...