by American Physiological Society Myocardial glucose uptake results. A: representative [18F]FDG PET/CT vertical long axis images showing Ki of the heart after secretin and placebo infusions (n = 1). Short axis images are shown in Supplemental Fig. S1. (see https://doi.org/10.6084/m9.figshare.16912807). B: the effect of secretin infusion on myocardial glucose uptake compared with placebo (n = 15)....
Category: <span>Metabolic</span>
Novel therapeutic approach to tackle obesity shows promise in lab trials
by Nanyang Technological University The therapeutic approach developed by NTU Singapore starts with an injection of a specially developed hydrogel using an insulin needle, into a fat deposit directly under the skin. After the hydrogel is injected, near infrared light is then shone on the site of injection. This activates the gel’s fat-burning ability. Credit:...
Researchers identify estrogen-regulated brain circuit that helps females control obesity
by Baylor College of Medicine Credit: Pixabay/CC0 Public Domain Seeking to better understand the key role the female hormone estrogen plays in maintaining energy balance and weight control, a group led by researchers at Baylor College of Medicine looked into estrogen interactions with specific brain regions that provide these anti-obesity benefits. The team reveals in...
Obesity in mice lowered by increasing effects of key weight-regulating hormone
JANUARY 17, 2022 by University of Michigan Credit: Pixabay/CC0 Public Domain Blocking the activity of an enzyme inside fat cells can decrease obesity and related health disorders in mice, according to new research led by the University of Michigan Life Sciences Institute. The study, published online Jan. 17 in the journal Nature Metabolism, focused on an enzyme...
‘Male menopause’ is real and treatable, say pharmacy researchers
Fatigue, weight gain, and low libido are just three of the symptoms middle-aged and older men face as their testosterone levels decline, but many don’t realize what’s going on. Sometimes referred to as “male menopause” or “manopause” in reference to the symptoms women experience when their estrogen levels drop, the medical term for men is...
Intestinal bacteria modulate metabolism: link to obesity
The bacteria inside our guts are fine-tuning our metabolism, depending on our diet, and new research suggests how they accomplish it. Emory researchers have identified an obesity-promoting chemical produced by intestinal bacteria. The chemical, called delta-valerobetaine, suppresses the liver’s capacity to oxidize fatty acids. The findings were recently published in Nature Metabolism. Image credit: Emory University...
Key hormone influences social behavior from areas outside the brain
by Mark Blackwell Thomas, Florida State University Preference for social novelty behaviors were similar in OXTRAvil WT and KO males and females. OXTRAvil mice displayed a preference for social novelty—a preference for a tower holding a novel stranger mouse (stranger tower; gray markers) over a tower holding a familiar mouse (familiar tower; white markers)—as evident by increased...
COVID-19 vaccination associated with a small, temporary increase in menstrual cycle length, study suggests
by NIH/Eunice Kennedy Shriver National Institute of Child Health and Human Development Credit: Unsplash/CC0 Public Domain Women receiving one dose of a COVID-19 vaccine during a single menstrual cycle had an increase in cycle length of nearly one day, compared to unvaccinated women, according to a study funded by the National Institutes of Health. The...
SOME PEOPLE IN GREENLAND ABSORB SUGAR DIFFERENTLY
According to a new study, gut bacteria and a unique diet that has nourished Greenlanders for millennia have provided them with a genetic variation that offers an incredible advantage. Two copies of a gene variant make it so that they absorb sugar differently than other people do. “Adult Greenlanders with the genetic variation have lower...
Breakthrough in using CRISPR-Cas9 to target fat cells
Fat—it is vital for life but too much can lead to a host of health problems. Studying how fat, or adipose, tissue functions in the body is critical for understanding obesity and other issues, yet structural differences in fat cells and their distribution throughout the body make doing so challenging. “Fat cells are different from...