Miriam E. Tucker May 24, 2021 A peripherally acting substance that boosts energy expenditure and reduces fat mass has the potential to become an obesity treatment that doesn’t produce cardiovascular or psychiatric side effects, scientists say. The agent, BIBO3304, is a selective antagonist of the neuropeptide Y1 receptor, which is elevated in the fat tissue of individuals with obesity,...
Category: <span>Metabolic</span>
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Glioblastoma study discovers protective role of metabolic enzyme, revealing a novel therapeutic target
UNIVERSITY OF TEXAS M. D. ANDERSON CANCER CENTER IMAGE: FROM LEFT TO RIGHT: FRANCESCA PUCA, PH.D., ANDREA VIALE, M.D., AND GIULIO DRAETTA, M.D., PH.D. CREDIT: MD ANDERSON CANCER CENTER HOUSTON – Researchers at The University of Texas MD Anderson Cancer Center have discovered a novel function for the metabolic enzyme medium-chain acyl-CoA dehydrogenase (MCAD) in glioblastoma (GBM)....
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Intermittent fasting may improve long-term memory
MAY 25, 2021 by John Anderer LONDON — Intermittent fasting (IF) is becoming a common practice among dieters trying to burn fat and lose weight, but a new study finds it may hold cognitive benefits as well. Researchers from Kings College London report IF helped improve the long term memory retention of a group of lab mice. Moreover,...
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Scientists discover new role for bile acids: They curb appetite by entering the brain
by Ecole Polytechnique Federale de Lausanne Neuronal cell line (mHypoE-N41) transfected with NPY-mCherry (in red) and stained with phalloidin to label the actin cytoskeleton (in green). In this cell TGR5 was activated by its selective agonist INT-777 and this activation caused the stabilization and polymerization of the actin fibers (green) and the consequent accumulation of NPY...
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Semaglutide New Drug Combo Well-Tolerated, Leads to Weight Loss
Becky McCall May 19, 2021 Combining an investigational agent, cagrilintide (Novo Nordisk), with semaglutide, a glucagon-like peptide-1 (GLP-1) agonist, leads to greater weight loss than semaglutide alone in people with a body mass index (BMI) over 27 kg/m2, and the combination was well-tolerated, shows a phase 1 study. The research was presented at the online ECO 2021 meeting by Lone...
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Researchers discover a new mechanism that regulates cholesterol levels
by University of Oulu Credit: CC0 Public Domain A research team at the University of Oulu, Finland, has discovered a new mechanism in cells that causes an increase in harmful LDL cholesterol. The observation made by the researchers may explain the adverse effects of certain environmental chemicals and medicinal substances on cardiovascular health. At the heart of the finding...
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Lipid droplets help protect kidney cells from damage
by The Francis Crick Institute Credit: The Francis Crick Institute Researchers at the Francis Crick Institute have found out how microscopic structures called lipid droplets may help to prevent a high-fat diet causing kidney damage. The work in fruit flies, published in PLoS Biology opens up a new research avenue for developing better treatments for chronic...
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Food dyes may cause disease when the immune system is dysregulated, researchers report
by The Mount Sinai Hospital Credit: Pixabay/CC0 Public Domain Artificial food colorants can cause disease when the immune system has become dysregulated, Icahn School of Medicine at Mount Sinai researchers report. The study, published in Cell Metabolism in May, was the first to show this phenomenon. The study, conducted in mice, found that the mice developed colitis when they consumed...
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Phenomenon explains why patients who survive sepsis die sooner after hospital discharge
FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO IMAGE: A REVIEW ARTICLE SHOWS THAT ALTERATIONS IN THE DEFENSE CELL METABOLISM MAY EXPLAIN WHY MANY PATIENTS WHO SURVIVE SEPSIS DIE WITHIN A YEAR OR SUFFER FROM LONG-TERM COMPLICATIONS. CREDIT: TALITA SOUZA-SIQUEIRA An article published in Frontiers in Immunology suggests that sepsis can cause alterations in the functioning of...
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Boosting body heat production: A new approach for treating obesity
GARVAN INSTITUTE OF MEDICAL RESEARCH IMAGE: CO-SENIOR AUTHOR DR YAN-CHUAN SHI CREDIT: GARVAN INSTITUTE A receptor that helps conserve energy when food is scarce may be the key to a safer approach to treating diet-induced obesity, research led by the Garvan Institute of Medical Research has revealed. In a study using experimental models and fat tissue biopsies from obese individuals,...