by Perelman School of Medicine at the University of Pennsylvania Credit: CC0 Public Domain It has been known for some time that the thyroid gland is a strong regulator of the body’s metabolism, making it key to many health conditions. But the molecular details of how thyroid hormone acts on cells in the body have never...
by University of Pittsburgh Ball-and-stick model of the dopamine molecule, a neurotransmitter that affects the brain’s reward and pleasure centers. Credit: Jynto/Wikipedia Why do patients who receive antipsychotic medications to manage schizophrenia and bipolar disorder quickly gain weight and develop prediabetes and hyperinsulemia? The question remained a mystery for decades, but in a paper published today...
by Uppsala University Credit: Pixabay/CC0 Public Domain Researchers from Uppsala University show in a new study that inhibition of the protein EZH2 can reduce the growth of cancer cells in the blood cancer multiple myeloma. The reduction is caused by changes in the cancer cells’ metabolism. These changes can be used as markers to discriminate whether a...
by University College London Credit: Pixabay/CC0 Public Domain One third (35%) of people who took a new drug for treating obesity lost more than one-fifth (greater than or equal to 20%) of their total body weight, according to a major global study involving UCL researchers. The findings from the large-scale international trial, published today in the New...
UNIVERSITY OF SOUTHERN CALIFORNIA IMAGE: USC ASSISTANT PROFESSOR OF GERONTOLOGY CHANGHAN DAVID LEE CREDIT: STEPHANIE KLEINMAN/USC A mitochondrial hormone expressed by cells deep in the brain appears to play a role in improving metabolism and fighting off obesity, according to a new study in mice. A collaboration between the USC Leonard Davis School of Gerontology...
by Yale University Bone marrow aspirate showing acute myeloid leukemia. Several blasts have Auer rods. Credit: Wikipedia In a new study led by Yale Cancer Center, researchers have discovered a novel metabolic gatekeeper mechanism for leukemia. This mechanism depends on a molecule called PON2, which could lead to a new treatment for the disease. The findings were published...
by Memorial Sloan Kettering Cancer Center Killer T cells surround a cancer cell. Credit: NIH The year 2021 marks the 100th anniversary of a fundamental discovery that’s taught in every biochemistry textbook. In 1921, German physician Otto Warburg observed that cancer cells harvest energy from glucose sugar in a strangely inefficient manner: rather than “burn” it...
by University of California – San Diego Credit: CC0 Public Domain Researchers at University of California San Diego School of Medicine, in collaboration with Dutch scientists, have found that certain metabolites—small molecules produced by the process of metabolism—may be predictive indicators for persons at risk for recurrent major depressive disorder. The findings were published in the January...
SHRINERS HOSPITALS FOR CHILDREN IMAGE: LEAD AUTHOR OF THE STUDY, DR. KELSEY COLLINS IS A POSTDOCTORAL FELLOW IN GUILAK’S LABORATORY. CREDIT: SHRINERS HOSPITALS FOR CHILDREN (St. Louis) – A new study by investigators at the Shriners Hospital for Children — St. Louis suggests the damaging effects of obesity are not due to body weight but...
by Rockefeller University energy and scientists hope it may hold the key to new obesity treatments. But it has long been unclear whether people with ample brown fat truly enjoy better health. For one thing, it has been hard to even identify such individuals since brown fat is hidden deep inside the body. Now, a new...
