by Medical University of Vienna Obesity is a serious global health problem and a risk factor for diseases such as type II diabetes, heart disease and fatty liver disease. A central element in the development of obesity is adipose tissue, which comprises fat cells (so-called adipocytes, specialized to store fat) and macrophages (immune system scavenger cells,...
UNIVERSITY OF WISCONSIN-MADISON MADISON, Wis. — Researchers have discovered a previously unknown way that pancreatic cells decide how much insulin to secrete. It could provide a promising new target to develop drugs for boosting insulin production in people with Type 2 diabetes. In a pair of papers recently published in Cell Metabolism, scientists from the University of Wisconsin-Madison...
Night-shift workers face an increased risk of obesity and diabetes, but the underlying reason for that has been a mystery. Now, University of Missouri School of Medicine researchers have found a potential cause for metabolic changes during night-shift work that creates confusion between cells in the body and the central clock in the brain. “We hypothesized that the...
by Amy Norton, Healthday An experimental antibody drug that targets one of the body’s key metabolism regulators may help obese people lose weight—at least briefly. That’s one finding from an early study that tested the injection drug, which mimics the effects of a natural hormone called fibroblast growth factor 21 (FGF21). In the body, FGF21...
by VIB (the Flanders Institute for Biotechnology) Representative images of embryonic myosin heavy chain (eMyHC) expression in TA muscle 6 days after CTX injury. A team headed by Prof. Massimiliano Mazzone (VIB-KU Leuven Center for Cancer Biology), in collaboration with Dr. Emanuele Berardi and Dr. Min Shang, revealed a new metabolic dialogue between inflammatory cells and...
by Medical University of Vienna Retinol or Vitamin A 3D space model (balls model). A recent study conducted by a research team led by Florian Kiefer from MedUni Vienna’s Division of Endocrinology and Metabolism shows that cold ambient temperatures increase vitamin A levels in humans and mice. This helps convert “bad” white adipose tissue into “good” brown adipose...
by Karolinska Institutet In a new study published in the journal Cell Death & Differentiation, researchers at Karolinska Institutet have conducted a translational study that identified a new mechanism for controlling the breakdown of glucose in several different cancer forms. The discovery could lead to new therapeutic strategies aimed to reduce cancer growth. A common problem with the current...
Researchers have uncovered new clues to the mystery of how the gut’s nervous system affects glucose metabolism in the rest of the body. Their findings could lead to new treatments for type 2 diabetes. Type 2 diabetes causes the body’s cells to become less sensitive to signals from insulin, the hormone responsible for regulating levels of...
CLEVELAND CLINIC CLEVELAND: A Cleveland Clinic study shows that 5 to 10 percent of surgically induced weight loss is associated with improved life expectancy and cardiovascular health. In comparison, about 20 percent weight loss is necessary to observe similar benefits with a non-surgical treatment. The findings also show that metabolic surgery may contribute health benefits...
by Katherine Fenz, Rockefeller University A cross section of the colon with enteric neurons highlighted. These neurons interface directly with gut microbes. Credit: Rockefeller University The 10 trillion bacteria living in your digestive system may not be human, but they seem to be as integral to your body as your heart or liver. A growing number...
