by Deb Balzer, Mayo Clinic Credit: Mayo Clinic News NetworkDe Quervain’s tenosynovitis (pronounced da-KWUHR-vanes teena-sine-ah-VITE-us) is a complicated name for a condition that’s been referred to as “mother’s thumb,” “mommy wrist” and “gamer’s thumb”—all associated with repetitive use of the hands and wrist. It is a condition that causes extreme pain in the wrist and...
by Elsevier Diagram of neuroinflammation in endometriosis. Researchers propose that IL-1β activates IL-1 type 1 membrane receptor (IL-1R1) in endometrial stromal cells, predominantly via the c-Jun N-terminal kinase (JNK) pathway, to promote neurotrophin and neurotrophin receptor (NTR) production and signaling, which in turn activate neurogenesis and pain. Parallel pathways promote IL-6 production and IL-1β autoregulation, potentially...
NEW YORK UNIVERSITY IMAGE: AN ARTISTIC REPRESENTATION OF THE INTERACTION BETWEEN THE NAV1.7 SODIUM ION CHANNEL AND COLLAPSIN RESPONSE MEDIATOR PROTEIN 2 (CRMP2). THE RESEARCHERS IDENTIFIED A UNIQUE REGULATORY SEQUENCE IN NAV1.7 THAT IS REQUIRED FOR NAV1.7 FUNCTION. THEY FOUND THAT THIS PEPTIDE DISRUPTED THE INTERACTION WITH CRMP2 AND REDUCED EXCITABILITY IN SENSORY NEURONS. THE...
By UNIVERSITY OF SYDNEY JULY 6, 2023 Analysis of global data spanning over 30 years reveals a growing crisis of low back pain, with projections suggesting 843 million people will suffer from the condition by 2050 due to the increasing population and aging demographics. A review of more than three decades of data reveals an escalating trend...
CELL PRESS IMAGE: THIS DIAGRAM SHOWS HOW NK CELL FUNCTION COULD IN THEORY RESULT IN THE RESOLUTION OF NEUROPATHIC PAIN IN THE CONTEXT OF PERIPHERAL NERVE INJURY BY DIRECTED CYTOTOXICITY AGAINST A NUMBER OF PATHOLOGICAL CELLULAR TARGETS. CREDIT: KIM ET AL./TRENDS IN NEUROSCIENCES In the midst of a global opioid epidemic, a team of scientists...
Eve Bender June 02, 2023 A novel intervention that blends individualized care, mindfulness, and a tapering plan is more successful than usual care in helping patients discontinue opioids for chronic pain, new research shows. As part of the multisite Improving the Wellbeing of People with Opioid Treated Chronic Pain (I-WOTCH) study, 30% of participants in the intervention...
by King’s College London Attenuated inflammatory arthritis pain in TASTPM is caused by microglia that are insensitive to Gal-3. a Illustration of the superficial laminae of the dorsal horn of the spinal cord, where nociceptor terminals synapse on laminae I projection neurons. b In homoeostasis, microglia constantly survey the parenchyma by responding to cues in their microenvironment. c During inflammatory arthritis, TLR4+ P2Y12+ microglia...
UNIVERSITY OF ESSEX IMAGE: AN EXAMPLE OF A GAMMA OSCILLATION BRAIN PAIN FINGERPRINT CREDIT: UNIVERSITY OF ESSEX New research has revealed everyone’s brain has a ‘pain fingerprint’ that varies from person to person. The University of Essex-led study, in collaboration with the neuroscience of pain group at the Ludwig Maximilians University of Munich, found fast-oscillating brain waves...
Manya Singh Updated: June 13, 2023 2:58 pm IST Stretching is a great way to reduce chronic pain, especially pain in the back and neck Exercising has been found to be a very effective way of reducing chronic pain. Chronic pain is the type of pain that persists for more than three months. Chronic pain...
by National Institutes of Health Credit: Unsplash/CC0 Public Domain For the first time, researchers have recorded pain-related data from inside the brain of individuals with chronic pain disorders caused by stroke or amputation (phantom limb pain). A long sought-after goal has been to understand how pain is represented by brain activity and how to modulate that activity to...
