by Chinese Academy of Sciences Retrograde AAV selectively targets D1-MSNs and rescues parkinsonian symptoms with chemogenetic modulation. Credit: SIAT Researchers from the Shenzhen Institute of Advanced Technology (SIAT) of the Chinese Academy of Sciences (CAS) and their collaborators have developed a gene therapy strategy to selectively manipulate Parkinson’s disease-affected circuitry and attenuate the core motor symptoms...
By Simar Bajaj July 10, 2023 Richard Huckabee, seen with his wife, Angela, says it took nine years to be diagnosed with Parkinson’s. COURTESY RICHARD HUCKABEE It took Richard Huckabee nine years to get a Parkinson’s diagnosis. A district manager for a convenience store chain, he first noticed symptoms in 2004 when his voice would...
This transcript has been edited for clarity. Welcome to Impact Factor, your weekly dose of commentary on a new medical study. I’m Dr F. Perry Wilson of the Yale School of Medicine. The thing to realize about this story is that even if it were just a problem for the military, it would be a huge problem. But...
by Justin Jackson, Medical Xpress Credit: Unsplash/CC0 Public Domain Research led by Kosin University College of Medicine in Korea has found a correlation between patients with rheumatoid arthritis and Parkinson’s disease. In their paper published in JAMA Neurology, researchers found a significantly higher risk of Parkinson’s disease (PD) in patients with rheumatoid arthritis (RA). In a cohort study of...
Megan Brooks May 12, 2023 A common gut bacteria may play a role in the development of Parkinson’s disease (PD) by causing aggregation of the alpha-synuclein protein, a key feature in the pathology of PD, a small study suggests. Environmental factors as well as genetics are also suspected to play a role in PD etiology, although the exact cause...
by Justin Jackson , Medical Xpress Shifted microbial composition across the prodromal and early stages of α-synucleinopathy. a Principal coordinates analysis (PCoA) of microbial communities across control (n = 108), RBD-FDR (n = 127), RBD (n = 170), and early PD (n = 36) based on Bray–Curtis distance matrix at the genus level. The label of each group indicates group centroid. Boxplots along...
by University of Helsinki Aggregation of alpha-synuclein in a nerve cell. Credit: Timo Myöhänen research group There are currently 8 million patients with Parkinson’s disease in the world. In 2021, Professor Per Saris’s group published results demonstrating that bacteria of the Desulfovibrio bacterial genus correlate with Parkinson’s disease, and that their higher number also correlates with the severity of the...
UNIVERSITY OF SOUTHERN DENMARK When a patient experiences the first symptoms of Parkinson’s disease, the disease has been developing for a long time, and the patient may have already lost half of a specific type of nerve cells in the brain. Therefore, researchers are focused on understanding what happens to these brain cells before they become damaged...
By Chuck Dinerstein, MD, MBA — April 18, 2023 “Our findings suggest that the αSyn-SAA technique is highly accurate at detecting the biomarker for Parkinson’s disease regardless of the clinical features,” says Luis Concha, Ph.D., “making it possible to accurately diagnose the disease in patients at early stages.” For those in the Parkinson’s Disease community, this is...
by Medical University of South Carolina Credit: Pixabay/CC0 Public Domain Like many neurodegenerative diseases, Parkinson’s disease (PD) is a thief that hacks into human operating systems and corrupts their cognitive hard drives until they can no longer control their movements or perform activities of daily living. Often, in its later stages, Parkinson’s disease steals data too,...
