More research is needed to determine the benefits and harms of osteoporosis medications on bone mineral density (BMD), fracture risk, and safety among patients with chronic kidney disease (CKD). This is important because complications of CKD include weak bones and increased fracture risk. The results of a systematic review and meta-analysis are published in Annals...
Category: <span>Pharmaceutical Updates</span>
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Taking a combination of painkillers and gastric protection damages the intestines
Patients suffering from inflammatory diseases are often prescribed NSAIDs. They are also prescribed PPI (Proton pump inhibitor) to protect their stomach. In a joint study, clinical pharmacologist Markus Zeitlinger and gastroenterologist Werner Dolak from MedUni Vienna showed that this combination of medication can result in inflammation in the small intestine. However, if an additional antibiotic...
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Scientists Discover New Class of Anti-Diabetes Compounds that Reduce Liver Glucose Production
JUPITER, FL – March 27, 2017 – Scientists may have found a new tool for studying—and maybe even treating—Type 2 diabetes, the form of diabetes considered responsible for close to 95 percent of cases in the United States. A team of scientists from the Florida campus of The Scripps Research Institute (TSRI), Dana-Farber Cancer Institute,...
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Homing System Delivers Drugs to Specific Neurons
Biomedical engineers have developed a way to deliver drugs to specific types of neurons in the brain, providing extraordinary ability to study neurological diseases and also a promising pathway to treat them. Drugs are the tool of choice for studying the connections between neurons and continue to be the mainstream treatment for neurological disease. But...
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Reversing diabetes with a new drug
In Brief Scientists have used a new drug to reverse diabetes in mice. The drug inhibits the enzyme LMPTP, which contributes to the development of Type 2 diabetes by weakening the body’s sensitivity to the hormone. Defining Diabetes In the global community, the number of people with diabetes has been on the rise since 1980, with...
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First photoactive drug for pain treatment
A team of the Institute of Neurosciences of the University of Barcelona has participated in the design of the first light-activated drug, JF-NP-26, for the treatment of pain, according to a study with animal models published in the journal eLife. The new study is conducted by the teams led by Professor Francisco Ciruela, from the University...
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Benefits and Harms of Osteoporosis Medications in Patients With Chronic Kidney Disease: A Systematic Review and Meta-analysis
Abstract Background: Complications of chronic kidney disease (CKD) include weak bones and increased fracture risk. Purpose: To review the benefits and harms of osteoporosis medications (bisphosphonates, teriparatide, raloxifene, and denosumab) compared with placebo, usual care, or active control in terms of bone mineral density (BMD), fractures, and safety in patients with CKD. Data Sources: PubMed...
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Benefits and harms of osteoporosis medications unclear for patients with CKD
ore research is needed to determine the benefits and harms of osteoporosis medications on bone mineral density (BMD), fracture risk, and safety among patients with chronic kidney disease (CKD). This is important because complications of CKD include weak bones and increased fracture risk. The results of a systematic review and meta-analysis are published in Annals of...
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Reversing Diabetes with a completely new drug
In Brief: Scientists have used a new drug to reverse diabetes in mice. The drug inhibits the enzyme LMPTP, which contributes to the development of Type 2 diabetes by weakening the body’s sensitivity to the hormone. Defining Diabetes: In the global community, the number of people with diabetes has been on the rise since 1980, with...
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Taking a combination of painkillers and gastric protection damages the intestines
Additonal given antibiotic (rifaximin) helps to protect the intestines. Credit: Medical University of Vienna Patients with inflammatory diseases are often prescribed non-steroidal anti-inflammatory drugs. They are also often prescribed a proton pump inhibitor to protect their stomach. In a joint study, clinical pharmacologist Markus Zeitlinger and gastroenterologist Werner Dolak from MedUni Vienna showed that...