Cancer cells obtained from a blood test may be able to predict how early-stage lung cancer patients will fare, a team from the University of Michigan has shown. This information could be used to determine which patients are most likely to benefit from additional therapies to head off the spread of the cancer to other...
Category: <span>Prognostic</span>
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Autoimmune diseases increase cardiovascular and mortality risk
Confirmed thanks to the monitoring of almost 1 million people over a six-year period Researchers from the Hospital del Mar Medical Research Institute (IMIM) and IDIAP Jordi Gol have just published an article showing that autoimmune diseases significantly increase cardiovascular risk as well as overall mortality. This is particularly pronounced in people suffering rheumatoid arthritis...
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Cartilage degeneration algorithm predicts progression of osteoarthritis
A novel cartilage degeneration algorithm can predict the progression of osteoarthritis in individual patients, according to new research from the University of Eastern Finland. The new algorithm could greatly facilitate clinical decision-making in the treatment of osteoarthritis. Osteoarthritis (OA) is a joint disease that deteriorates the articular cartilage. The most important risk factors are ageing and...
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Thoracic kyphosis in those over 50 may not be a predictor of physical decline
BOSTON — A recently published study in the Journal of the American Geriatrics Society has found that using CT scans to evaluate early signs of hyperkyphosis (extreme forward curvature of the upper spine) in people over age 50 does not help to identify those at risk of subsequent physical function decline. The article’s conclusions are based on...
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Study identifies miR122 target sites in liver cancer and links a gene to patient survival
A new study of a molecule that regulates liver-cell metabolism and suppresses liver-cancer development shows that the molecule interacts with thousands of genes in liver cells, and that when levels of the molecule go down, which often happens during liver-cancer development, the activity of certain cancer-promoting genes goes up. The findings could one day help...
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Telomere length prognostic in hepatocellular carcinoma
Li-Jie Ma, from Fudan University in Shanghai, and colleagues used telomere-specific fluorescence in situ hybridization and quantitative polymerase chain reaction to assess telomere length in HCC cell lines, tumor tissues, and nontumor cells within the tumor. The researchers found that, compared with their normal counterparts, significant telomere attrition was found in tumor cells and cancer-associated fibroblasts (CAFs), but...
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Reaction time variation may be a marker that predicts mortality in old age
A common indicator of neurobiological disturbance among the elderly may also be associated with mortality, according to a study published August 9, 2017 in the open access journal PLOS ONE by Nicole A. Kochan at the Centre for Healthy Brain Ageing (CHeBA), UNSW Sydney. Intraindividual reaction time variability (IIVRT), defined as an individual’s variation in reaction times...
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Researchers Identify Strong Prognostic Indicators of Survival Following Pancreatic Tumor Removal
New Rochelle, NY, August 10, 2017—A new study of patients who underwent curative surgical removal of a pancreatic ductal adenocarcinoma showed that two of the nine preoperative factors analyzed were strongly predictive of poor prognosis regardless of the tumor stage. Preoperative assessment of these prognostic biomarkers might help in planning treatment strategies to improve patient outcomes,...
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Differences in subtypes of gastric cancer may determine prognosis and response to treatment
In 2014, The Cancer Genome Atlas (TCGA) project discovered that there are four molecular subtypes of gastric cancer: Epstein-Barr virus subtype (EBV); microsatellite instability subtype (MSI); genomically stable subtype (GS); and chromosomal instability subtype (CIN). Lee said most patients with early-stage gastric cancer are treated with a surgical resection, followed by chemotherapy. “However, outcomes vary...
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‘Fitness and fatness’: Not all obese people have the same prognosis; second study sheds light on ‘obesity paradox’
People can be obese but metabolically healthy and fit, with no greater risk of developing or dying from cardiovascular disease or cancer than normal weight people, according to the largest study ever to have investigated this seeming paradox. The findings show there is a subset of obese people who are metabolically healthy — they don’t...