This article by Dr. Claudia Stefanutti et al. is published in Current Pharmaceutical Design, Volume 24 , Issue 31 , 2018 BENTHAM SCIENCE PUBLISHERS Research suggests a specific treatment for Homozygous Familial Hypercholesterolaemic (HoFH) patients; combination therapy with PCSK9–inhibitors (PCSK9-I) and lipoprotein–apheresis (LA) may have synergistic effects on circulating lipid and lipoprotein levels. The relationship with the treatment regimen mentioned above...
Category: <span>Proteomics</span>
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The role of PCSK9 in the pathogenesis of non-alcoholic fatty liver disease
This article by Dr Eleni Theocharidou et al. is published in Current Pharmaceutical Design, Volume 24, Issue 31, 2018 BENTHAM SCIENCE PUBLISHERS Statin treatment exhibits a beneficial effect in patients of cardiovascular diseases (CVD) and non–alcoholic fatty liver disease (NAFLD). Statins are common treatments for such conditions. The role of proprotein convertase subtilisin kexin type-9 (PCSK9) in the pathogenesis of NAFLD is summarized...
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Experimental treatment shows promise against triple-negative breast cancer
Mouse study illustrates the potential efficacy of Tinagl1 protein PRINCETON UNIVERSITY By simultaneously tackling two mechanisms for cancer’s growth, an experimental therapy reduced the spread of triple-negative breast cancer in a study conducted in mice. IMAGE: TREATMENT WITH RECOMBINANT TINAGL1 PROTEIN SIGNIFICANTLY SUPPRESSED LUNG METASTASIS, AS SHOWN BY THE BLUE ARROWS IN MICE WITH (RIGHT) OR WITHOUT...
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Study sheds light on the function of a long-mysterious PCSK9 mutation
Results build on developing model of new druggable PCSK9 interactor AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY High levels of low-density lipoproteins, parcels of lipids and protein that carry cholesterol, are a leading risk factor for heart disease. Many cholesterol medications lower LDL, some of them by targeting the protein PCSK9. In the January issue of the...
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Synaptic protein regulates anxiety behaviour
Anxiety disorders are severe mental disorders in which patients suffer from intense fears and anxiety or from sudden, inexplicable panic attacks. In extreme cases, the affected individuals barely leave their homes, which can have serious consequences for their relationships with family and friends as well as for their professional lives. Scientists at the Max Planck...
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Septin proteins act as cellular police to identify, imprison and kill ‘superbug’ Shigella
Ground-breaking discovery reveals new clues to stop the spread of deadly infections LONDON SCHOOL OF HYGIENE & TROPICAL MEDICINE Using state-of-the art technologies to image human cells and study infection at the level of a single bacterial cell, the research team, led by the London School of Hygiene & Tropical Medicine, has uncovered the strongest...
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Researchers give new insight to muscular dystrophy patients
New research by University of Minnesota scientists has revealed the three-dimensional structure of the DUX4 protein, which is responsible for the disease, facioscapulohumeral muscular dystrophy (FSHD). Unlike the majority of genetic diseases, FSHD is not caused by a protein that is missing or not functioning properly. Rather it is caused when a functioning, normal, protein...
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Honeybee protein keeps stem cells youthful
An active protein component of royal jelly helps honeybees create new queens. Stanford researchers have identified a similar protein in mammals, which keeps cultured embryonic stem cells pluripotent. Kevin Wang holds a flask of cells that have been engineered to produce the Regina protein, a mammalian protein similar in structure to the active component of...
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New molecular tool identifies sugar-protein attachments
Researchers at Johns Hopkins Medicine have developed a new molecular tool they call EXoO, which decodes where on proteins specific sugars are attached–a possible modification due to disease. The study, published in issue 14 of Molecular Systems Biology, describes the development of the tool and its successful use on human blood, tumors and immune cells....
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Good explanation of Proteins
In October 2010, an Italian religious historian named Alberto Melloni stood over a small cherrywood box in the reading room of the Laurentian Library, in Florence. The box was old and slightly scuffed, and inked in places with words in Latin. It had been stored for several centuries inside one of the library’s distinctive sloping...