A protein with a role in sensing cell damage and viral infections is a new target for the treatment of pulmonary hypertension, or increased blood pressure in the lungs, according to research led by Virginia Commonwealth University and the University of Sheffield in the United Kingdom. The disease can lead to heart failure because the heart must...
Category: <span>Proteomics</span>
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Drug candidate may recover vocal abilities lost to ADNP syndrome
Protein snippet normalizes disrupted neural connectivity caused by genetic disorder, Tel Aviv University researchers say AMERICAN FRIENDS OF TEL AVIV UNIVERSITY Activity-dependent neuroprotective protein syndrome (ADNP syndrome) is a rare genetic condition that causes developmental delays, intellectual disability and autism spectrum disorder symptoms in thousands of children worldwide. There is no known remedy for the disorder. A...
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Pathway to resolve allergic asthma is discovered
A group of Brazilian researchers succeeded in preventing allergic asthma from progressing in experimental models by increasing the amount of a protein. This increase, in turn, blocked the CD4+ T lymphocytes responsible for producing a cytokine that triggers a cascade of events resulting in the onset and progression of the disease. This knowledge of how...
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Dana-Farber scientists find new drug targets in aggressive cancers
BOSTON – Scientists have discovered a previously unknown molecular vulnerability in two rare, aggressive, and hard-to-treat types of cancer, and say it may be possible to attack this weakness with targeted drugs. Reporting in Nature Cell Biology, researchers at Dana-Farber Cancer Institute show that these two cancers – synovial sarcoma and malignant rhabdoid tumors –...
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Researchers identify promising proteins for diagnostic, prognostic use in ALS
Researchers from North Carolina State University have identified proteins that may be useful in both earlier diagnosis of Amyotrophic Lateral Sclerosis (ALS) and in more accurate disease prognosis. An MRI with increased signal in the posterior part of the internal capsule which can be tracked to the motor cortex consistent with the diagnosis of ALS....
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Cooling ‘brains on fire’ to treat Parkinson’s
A promising new therapy to stop Parkinson’s disease in its tracks has been developed at The University of Queensland. UQ Faculty of Medicine researcher Associate Professor Trent Woodruff said the team found that a small molecule, MCC950, stopped the development of Parkinson’s in several animal models. The NLRP3 inflammasome (green) is expressed by immune cells...
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Muscle-building proteins hold clues to ALS, muscle degeneration
Toxic protein assemblies, or “amyloids,” long considered to be key drivers in many neuromuscular diseases, also play a beneficial role in the development of healthy muscle tissue, University of Colorado Boulder researchers have found. Physician-scientists and competitive runners Josh Wheeler left, and Thomas Vogler on the summit of Long’s Peak in Colorado. Credit: CU Boulder...