Sanford Health is launching its second adipose-derived stem cell clinical trial – this one to focus on non-healing leg wounds. The trial, which opened in September with expanded criteria, is a phase 1 trial to study the safety and efficacy of using adipose-derived stem cell therapy as a treatment for non-healing leg ulcers. It’s open to participants...
Category: <span>Stem Cell Therapy</span>
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Phenogenetic Map Created For Stem Cell Models Of Neurological Diseases
COLUMBUS, Ohio – In an effort to better understand neurological diseases like Alzheimer’s, Parkinson’s and ALS – and develop new ways to treat them – researchers at The Ohio State University Wexner Medical Center have performed the first meta-analysis of all induced pluripotent stem cell models for neurological and neurodegenerative diseases, and created an atlas of how...
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Multiple sclerosis: Oligodendrocytes from stem cells
A scientific collaboration between stem cell researchers of the Heinrich-Heine-University led by Prof. Küry (Dept. of Neurology) and by Prof. Adjaye (Institute for Stem Cell Research and Regenerative Medicine) with support from British and Chilean colleagues resulted in a new publication on the prospective use of stem cells to generate cell replacement in diseases such...
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miR-26a Mediates Adipogenesis of Amniotic Fluid Mesenchymal Stem/Stromal Cells via PTEN, Cyclin E1, and CDK6.
Abstract Recent findings indicate that microRNAs (miRNAs) are critical for the regulatory network of adipogenesis in human mesenchymal stem/stromal cells (MSCs). Fetal MSCs derived from amniotic fluid (AF-MSCs) represent a population of multipotent stem cells characterized by a wide range of differentiation properties that can be applied in cell-based therapies. In this study, miRNA microarray...
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Differentiation of mesenchymal stem cells from human amniotic fluid to vascular endothelial cells
Highlights • We found that the mesenchymal stem cells can be isolated from the second trimester of human amniotic fluid by the adherence method, which is inexpensive and easy to perform. Additionally, the amniocentesis procedure has no problem about contamination. • We have demonstrated that the human amniotic fluid-derived mesenchymal stem cells (hAF-MSCs) exhibited typical MSCs characteristics including displaying the fibroblast-liked morphology and the...
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Team creates functional, stem-cell-derived small bowel segments
A decellularized loop of rat small bowel after repopulation, with stem-cell-derived human epithelial cells (green) lining the intestine and endothelial cells (red) lining the blood vessels. Using human induced pluripotent stem cells (iPSCs), a Massachusetts General Hospital research team has bioengineered functional small intestine segments that, when implanted into rats, were capable of deliver...
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Dentists Find Tooth Root Pulp Can Become an Alternative Source of Stem Cells
IN BRIEF A team of dentists and scientists from the University of Nevada, Las Vegas has found a rich new source of stem cells. Tooth root pulps, they discovered, were home to both pluripotent and multipotent cells. The team also developed a way to extract them without damaging the cells. WISDOM IN TEETH A collaboration...
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Stem cell gene therapy safe for adrenoleukodystrophy
(HealthDay)—Early results suggest that stem cell gene therapy is a safe and effective treatment for boys with early-stage cerebral adrenoleukodystrophy, according to a study published online Oct. 4 in the New England Journal of Medicine to coincide with the 2017 Child Neurology Society Annual Meeting, being held Oct. 4 to 7 in Kansas City. Florian Eichler, M.D.,...
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New method for tissue regeneration, inspired by nature, described by scientists
Scientists have found a way of mimicking our body’s natural healing process, using cell derived nano-sized particles called vesicles, to repair damaged tissue. The paper, published in Scientific Reports, describes a new approach to bone regeneration; stimulating cells to produce vesicles which can then be delivered to facilitate tissue regeneration. The research team, led by the University of Birmingham,...
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Umbilical cord stem cells show promise as heart failure treatment
Illustration of the heart. A heart failure treatment using umbilical cord-derived stem cells may lead to notable improvements in heart muscle function and quality of life, according to a new study published in Circulation Research, an American Heart Association journal. “We are encouraged by our findings because they could pave the way to a non-invasive, promising...