LUND UNIVERSITY Researchers at Lund University Faculty of Medicine have determined a novel mechanism linking the metabolism of ribonucleic acids, RNA, to the development of leukemia in myelodysplastic syndrome patients, MDS. In a study published in the Molecular Cell journal, they explain what makes hematopoietic stem cells acquire malignant traits in cancer. RNA splicing is a major...
Category: <span>Stem Cell Therapy</span>
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Researchers develop method to identify, sort and observe function in neural stem cells
by Justin Jackson , Medical Xpress Graphical abstract. Credit: Cell (2023). DOI: 10.1016/j.cell.2023.02.017 Researchers at Stanford University in California have devised a fluorescence-activated cell-sorting method for isolating distinct neural stem and progenitor cell types from human brain tissue. The markers used in the study are conserved across diverse brain regions. The technique should aid future research on...
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Meningref trial shows better protection against meningococcal infection in hematopoietic stem cell transplant recipients
INSTITUT PASTEUR The team in the Hematology Department at Henri Mondor AP-HP Hospital, coordinated by Dr. Christine Robin, and scientists from the Institut Pasteur (the Invasive Bacterial Infections Unit led by Professor Muhamed-Kheir Taha) recently studied protection against meningococcal infection in patients who had received hematopoietic stem cell transplantation. The results of this trial (NCT03509051), sponsored by...
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Improved survival in multiple myeloma patients following three-drug therapy with autologous stem cell transplant
by Dana-Farber Cancer Institute Credit: Pixabay/CC0 Public Domain Patients with multiple myeloma who have been treated with a three-drug combination therapy have a growing number of choices for subsequent treatment. Results of a new study led by researchers at Dana-Farber Cancer Institute can help patients and their physicians weigh benefits and risks of each option....
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A stem cell model could help unravel the complex biology behind some psychiatric disorders
by The Mount Sinai Hospital Graphical abstract. Credit: Cell Reports (2022). DOI: 10.1016/j.celrep.2022.110877 Researchers from the Icahn School of Medicine at Mount Sinai have applied a novel stem cell model to map disease risk variants in human neurons, which could help provide insights into the biological mechanisms that underlie neuropsychiatric disorders such as autism and schizophrenia. The...
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Stem Cell Transplantation a Potential Game Changer for MS?
Nancy A. Melville March 03, 2022 WEST PALM BEACH, Florida — Stem cell transplantation is tied to complete elimination of relapse in patients with aggressive multiple sclerosis (MS), new long-term data show. In a retrospective study, investigators found patients with aggressive MS treated with autologous hematopoietic stem cell transplant (aHSCT) experienced complete elimination of relapse, with no...
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dNovo’s novel baldness treatment takes a direct route to hair regrowth
By Nick Lavars February 06, 2022 dNovo has developed a promising new baldness treatment Depositphotos A new player has entered the hair loss scene promising a new form of treatment that takes a more efficient approach to regenerating lost follicles. Like many solutions in the space, dNovo’s technology uses hair stem cells to replace cells...
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Mouse experiments show how sugar molecules can be used to track stem cells
JOHNS HOPKINS MEDICINE IMAGE: UNLIKE MOST OTHER CELLS, MANNOSE RESIDUES (GREEN) ARE ABUNDANT ON THE MSC CELL MEMBRANE. USING AN MRI TECHNIQUE THAT IS SENSITIVE TO THE PRESENCE OF MANNOSE, TRACKING OF TRANSPLANTED MSCS IS NOW POSSIBLE WITHOUT THE NEED OF LABELING THEM. CREDIT: IMAGE COURTESY OF SHREYAS KUDDANNAYA EMBARGOED TILL MONDAY, FEB. 7 AT...
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Stem cell discoveries hold potential to improve cancer treatment
by Cedars-Sinai Medical Center Hematopoietic precursor cells: promyelocyte in the center, two metamyelocytes next to it and band cells from a bone marrow aspirate. Credit: Bobjgalindo/Wikipedia Two recent discoveries by stem cell scientists at Cedars-Sinai may help make cancer treatment more efficient and shorten the time it takes for people to recover from radiation and...
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New technique may lead to safer stem cell transplants
by Julia Evangelou Strait, Washington University School of Medicine Studying mice, researchers at Washington University School of Medicine in St. Louis have developed a method of stem cell transplantation that does not require radiation or chemotherapy. Above, the right panel shows mouse bone marrow after the debilitating effects of radiation followed by an infusion of donor...