Researchers have pinpointed a key enzyme that is vital for the production of fresh blood cells in the body. The enzyme is essential for the survival of specialised stem cells that give rise to new blood cells, the study found. Experts say the findings could help to improve the success of stem cell therapies that...
Category: <span>Stem Cell Therapy</span>
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Stem cell therapy holds promise for treating most severe cases of angina
An analysis of data from the entire development program consisting of three trials assessing the feasibility of using a stem cell therapy (CD34+ cells) to treat patients with the most severe cases of angina, refractory angina (RA), showed a statistically significant improvement in exercise time as well as a reduction in mortality. Results from “CD34+...
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With stem cells to new intervertebral discs
IMAGE: UZH RESEARCHERS DEMONSTRATE ON GERMAN SHEPHERDS THAT A TREATMENT WITH THE BODY’S OWN STEM CELLS ARE WELL TOLERATED It is the “shock absorber” between the vertebrae of the spine, cushioning every step, bend and jump: the intervertebral disc. If the fibrocartilage tissue in the spine degenerates over time, an intervertebral disc can “slip” –...
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Wound healing: The stem cell dynamic
Researchers at the Université libre de Bruxelles, ULB define for the first time the changes in the stem cell dynamics that contribute to wound healing. One of the key questions in biology is to identify how tissues are repaired after trauma and understand how stem cells migrate, proliferate, and differentiate to repair tissue damage. In...
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It’s all in the math: New tool provides roadmap for cell development
Topological representation of four cellular populations during motor neuron differentiation. Researchers at Columbia University Medical Center have created a new tool to describe the many possible ways in which a cell may develop. Rooted in the mathematical field of topology, the tool provides a roadmap that offers detailed insight into how stem cells give rise...
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New insights on triggering muscle formation
Lorenzo Puri, M.D., Ph.D. Researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) have identified a previously unrecognized step in stem cell-mediated muscle regeneration. The study, published in Genes and Development, provides new insights on the molecular mechanisms that impair muscle stem cells (MuSCs) during the age-associated decline in muscle function that typically occurs in...
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Scientists turn human induced pluripotent stem cells into lung cells
This is Finn Hawkins and Katherine McCauley. Human lungs, like all organs, begin their existence as clumps of undifferentiated stem cells. But in a matter of months, the cells get organized. They gather together, branch and bud, some forming airways and others alveoli, the delicate sacs where our bodies exchange oxygen for carbon dioxide....
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Stem cells edited to fight arthritis: Goal is vaccine that targets inflammation in joints
Using CRISPR technology, a team of researchers led by Farshid Guilak, PhD, at Washington University School of Medicine in St. Louis, rewired stem cells’ genetic circuits to produce an anti-inflammatory arthritis drug when the cells …more Using new gene-editing technology, researchers have rewired mouse stem cells to fight inflammation caused by arthritis and other chronic...
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Study signals need to screen genes for stem cell transplants
Regenerative medicine using human pluripotent stem cells to grow transplantable tissue outside the body carries the promise to treat a range of intractable disorders, such as diabetes and Parkinson’s disease. However, a research team from the Harvard Stem Cell Institute (HSCI), Harvard Medical School (HMS), and the Stanley Center for Psychiatric Research at the Broad...
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Stem cells may improve tendon healing, reduce retear risk in rotator cuff surgery
An injection of a patient’s bone marrow stem cells during rotator cuff surgery significantly improved healing and tendon durability, according to a study presented today at the 2015 Annual Meeting of the American Academy of Orthopaedic Surgeons (AAOS). Each year in the U.S., more than 2 million people have rotator cuff surgery to re-attach their shoulder tendon...