Iowa State University researchers, left to right, Metin Uz, Suprem Das, Surya Mallapragada and Jonathan Claussen are developing technologies to promote nerve regrowth. The monitor shows mesenchymal stem cells (the white) aligned along graphene circuits (the black). Researchers looking for ways to regenerate nerves can have a hard time obtaining key tools of their trade....
Category: <span>Stem Cell Therapy</span>
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From skin to brain: Stem cells without genetic modification
The top four images, from left to right, show Keratinocyte-derived neural crest stem cells turning into neurons as shown by typical neuronal morphology. The larger image, directly above, is a close-up of the far right image. A discovery, several years in the making, by a University at Buffalo research team has demonstrated that adult skin...
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Ability of stem cells expanded to regrow any tissue type
Human EPS cells (green) can be detected in both the embryonic part (left) and extra-embryonic parts (placenta and yolk sac, right) of a mouse embryo. When scientists talk about laboratory stem cells being totipotent or pluripotent, they mean that the cells have the potential, like an embryo, to develop into any type of tissue in...
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Stem cells help explain varied genetics behind rare neurologic disease
Researchers at Case Western Reserve University School of Medicine have successfully grown stem cells from children with a devastating neurological disease to help explain how different genetic backgrounds can cause common symptoms. The work sheds light on how certain brain disorders develop, and provides a framework for developing and testing new therapeutics. Medications that appear...
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From skin to brain: Stem cells without genetic modification
Summary: A discovery, several years in the making, demonstrates that adult skin cells can be converted into neural crest cells (a type of stem cell) without any genetic modification, and that these stem cells can yield other cells that are present in the spinal cord and the brain. The applications could be significant, from studying...
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Stem cell drug screen yields potential alternative to statins
IMAGE: THIS IS AN ILLUSTRATION FEATURING FOXGLOVE, THE PLANT FROM WHICH CARDIAC GLYCOSIDES ARE DERIVED. Scientists at the Medical University of South Carolina (MUSC) have found that a class of heart failure drugs might decrease low-density lipoprotein (LDL) cholesterol levels in patients who do not respond to statins. In a study appearing in the April...
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Molecular ‘GPS’ helps stem cells navigate inside the body
Recent research has identified a novel molecule that could help localise stem cells within the body. Cell therapy holds significant promise for treating a wide range of diseases and tissue defects including arthritis, cardiovascular disease, multiple sclerosis and Crohn’s disease. But in current therapies, most cell types do not reach diseased or damaged tissues efficiently....
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An alternative to Statins with Stem cell drug screen
Stem cell drug screen yields potential alternative to statins. A novel drug screen in liver-like cells produced from a patient’s stem cells shows that cardiac glycosides could reduce LDL cholesterol differently from statins, report researchers at the Medical University of South Carolina. In a study appearing in the April 6, 2017 issue of Cell Stem...
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Adult Stem Cell Therapy for Stroke: Challenges and Progress
Abstract Stroke is one of the leading causes of death and physical disability among adults. It has been 15 years since clinical trials of stem cell therapy in patients with stroke have been conducted using adult stem cells like mesenchymal stem cells and bone marrow mononuclear cells. Results of randomized controlled trials showed that adult...
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Mannitol-enhanced delivery of stem cells and their growth factors across the blood-brain barrier
Abstract Ischemic brain injury in adults and neonates is a significant clinical problem with limited therapeutic interventions. Currently, clinicians have only tPA available for stroke treatment and hypothermia for cerebral palsy. Owing to the lack of treatment options, there is a need for novel treatments such as stem cell therapy. Various stem cells including cells...