Induced pluripotent stem cells (iPSCs) — stem cells that are capable of differentiating into one of many cell types — are a technique that opens the doors to medical advances, including generating cartilage cell tissue to repair knees, …more It’s been more than 10 years since Japanese researchers Shinya Yamanaka, M.D., Ph.D., and his graduate...
Category: <span>Stem Cell Therapy</span>
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Rexgenero Treats Its First Patient In Phase III Clinical Trial of Bone Marrow-Based Critical Limb Ischemia Treatment
According to their website, Rexgenero is a “regenerative medicine company and developer of advanced cell-based therapeutics for the treatment of serious diseases that are poorly treated with existing therapies.” The head office of Rexgenero is in London, but their Research and Development laboratories are in Seville, Spain. They also have a United Kingdom office in Brighton, which...
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Improving longevity of functionally integrated stem cells in regenerative vision therapy
Image showing transplanted GFP-expressing human stem cell derived photoreceptors integrated in a host rodent retina stained for Otx2 in red. Stem cell therapies hold great promise for restoring function in a variety of degenerative conditions, but one of the logistical hurdles is how to ensure the cells survive in the body long enough to work....
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Stem cell strategy for boosting testosterone levels tested in rodents
Male hypogonadism is a condition that diminishes testosterone levels in approximately 30% of older men, but currently available therapies can produce serious side effects. In a study published December 22 in Stem Cell Reports, researchers developed an alternative approach involving the direct conversion of adult skin cells into functional testosterone-producing cells. When transplanted into male rodents...
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Scientists reprogram embryonic stem cells to expand their potential cell fates
miR-34a-deficient embryonic stem cell culture is enriched with cells with expanded developmental potential as shown by their strong MuERV-L induction (red). These cells are distinct from the classic embryonic stem cells shown by the Oct4 staining (green). MuERV-L are the family of murine endogenous retroviruses activated in the very early embryo. Researchers from the University...
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New findings about stem cells in the brain of patients with epilepsy
Neural stem cells have been found in epileptic brain tissue — outside the regions of the brain where they normally reside. In a group of patients who underwent surgery for epilepsy, over half had stem cells where healthy individuals do not have them, according to a study from Sahlgrenska Academy. “We have confirmed what earlier...
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CtIP-Specific Roles during Cell Reprogramming Have Long-Term Consequences in the Survival and Fitness of Induced Pluripotent Stem Cells
Highlights DNA end resection mechanism is hyper-activated during reprogramming CtIP protein levels increase during mouse and human cell reprogramming Loss of CtIP impairs mouse and human reprogramming efficiency Reprogramming without CtIP causes defects in iPSC self-renewal and differentiation Summary Acquired genomic instability is one of the major concerns for the clinical use of induced pluripotent...
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Lipid metabolism is potential ‘Achilles’ heel’ for cancer stem cells
WEST LAFAYETTE, Ind. — Researchers have discovered a metabolic signature critical for the functioning of “cancer stem cells” that initiate tumor formation. The team also showed how to interfere with this metabolic mechanism in ovarian cancer, inhibiting tumor growth. “The cancer stem cells are resistant to conventional therapies and are responsible for tumor relapse after...
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Stem cells used to regenerate the external layer of a human heart
Summary: A process using human stem cells can generate the cells that cover the external surface of a human heart — epicardium cells — according to a multidisciplinary team of researchers. Heart progenitors cells derived from human stem cells can be further specified to heart cells belong to external layer or muscle layer of a...
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Artists may unknowingly paint a picture of cognitive decline
Fractals in brush strokes may say a lot about the artist’s state of health(Credit:agencyby/Depositphotos) It’s not abnormal for the style of artists to evolve over time, but could very subtle changes represent something bigger than simply maturing tastes? Researchers at the University of Liverpool think they could. They’ve studied brushstrokes in thousands of paintings from...