INSTITUTO GULBENKIAN DE CIENCIA IMAGE: CHROMOSOME SEGREGATION IN A HUMAN INDUCED PLURIPOTENT STEM CELL. CENTROMERES IN GREEN AND DNA IN MAGENTA. Stem cells are considered one of the most promising tools in the field of regenerative medicine because they are a cell type that can give rise to all the cells in our bodies and...
by Sarah C.p. Williams, University of California, Los Angeles A section of an artificial thymic organoid showing T cells (outlined in green) created from blood stem cells. Researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have developed a way to make mouse thymus organoids that can be grown in the...
Hair loss seems like a minor problem to many. You got bald, so what? Some people prefer this look. However, for many men going bald is a terrible experience and they would pay good money to avoid it. Now scientists at the University of Helsinki have identified a mechanism that is likely to prevent hair...
by Boston Medical Center For the first time, researchers have successfully created airway basal stem cells in vitro from induced pluripotent stem cells by reprogramming blood cells taken from patients. Given that airway basal cells are defined as stem cells of the airways because they can regenerate the airway epithelium in response to injury, this study may help...
KUMAMOTO UNIVERSITY IMAGE: SINGLE MYOFIBERS WERE ISOLATED FROM MOUSE MUSCLE TISSUE IN A SUSPENSION CELL CULTURE. SATELLITE CELLS ON THE MYOFIBER WERE EXPOSED TO COMPONENTS LEAKING FROM DAMAGED MYOFIBERS FOR 72 HOURS BY.. While building a muscle damage model in a cultured system, a research collaboration between Kumamoto University and Nagasaki University in Japan has found that components leaking...
KUMAMOTO UNIVERSITY IMAGE: ERΒ CONTROLS MUSCLE GROWTH IN YOUNG FEMALE MICE ERΒ IS ESSENTIAL FOR MUSCLE REGENERATION IN FEMALE MICE INACTIVATION OF ERΒ CAUSES AN INCREASE IN APOPTOSIS ERΒ IS REQUIRED FOR SATELLITE CELL POPULATION EXPANSION Researchers at Kumamoto University, Japan generated mice lacking the estrogen receptor beta (ERβ) gene, both fiber-specific and muscle stem cell-specific, which...
UNIVERSITY OF HELSINKI Hair follicle stem cells, which promote hair growth, can prolong their life by switching their metabolic state. In experiments conducted with mice, a research group active in Helsinki and Cologne, Germany, has demonstrated that a protein called Rictor holds a key role in the process. The study was published in the Cell Metabolism journal. New information...
by Medical University of South Carolina This figure depicts the two major T-cell co-stimulation pathways, ICOS and CD28, targeted by the new drug candidate ALPN-101 as compared to CTLA-4-Fc CD28/B7 pathway inhibitors (abatacept and belatacept) for the treatment of graft-versus-host disease. A recent report published in Science Translational Medicine by MUSC Hollings Cancer Center investigator Sophie Paczesny, M.D.,...
Stem cells are cell factories that constantly divide themselves to create new cells. Implanting stem cells in damaged organs can regenerate new tissues. Cell sheet engineering, which allows stem cells to be transplanted into damaged areas in the form of sheets made up of only cells, completely eliminates immune rejection caused by external substances and...
UNIVERSITY OF WÜRZBURG T cells play a key role in the human immune system. They are capable of distinguishing diseased or foreign tissue from the body’s own, healthy tissue with great accuracy; they are capable of triggering the actions necessary to fight off the troublemakers. The details of this immune response are manifold and the...
