Manuela Callari XEN-D0501, a transient receptor potential vanilloid 1 (TRPV1) antagonist, is gaining attention for its potential as an oral tablet to treat type 2 diabetes, obesity, and cardiovascular diseases. Dorte X. Gram, PhD, founder of Pila Pharma, a Swedish pharmaceutical company investigating XEN-D0501, first noticed the connection more than 20 years ago as a researcher at...
Category: <span>Treatment</span>
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Antibodies that keep ancient viral DNA in check may inform new treatments
by Mallory Locklear, Yale University Schematic of fluorescence streptavidin-biotin–tagged ERV- and VLP-baiting strategy. Credit: Science Immunology (2024). DOI: 10.1126/sciimmunol.add6608 After viruses infected our evolutionary ancestors, bits of viral DNA lodged themselves into their genomes—and we still carry around genetic remnants of those viruses now. Known as endogenous retroviruses, these pieces of ancient invaders aren’t able to produce infectious...
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Parkinson’s disease a promising treatment- pharmaceutical
Parkinson’s disease: finally a promising treatment© Unsplash A sparkling shot… almost magical, to treat Parkinson’s. American researchers have conducted several clinical trials, rather encouraging. Gold nanocrystals that could restore molecules affected by neurodegenerative diseases? Really? To understand how they work, let’s take a quick look at “biology”. The brain, in order to function properly, needs a...
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Revolutionizing cartilage repair: The role of macrophages and hyaluronic acid in healing injuries
by NYU Tandon School of Engineering Researchers found that Intra-articular injections of P15-1 together with high-molecular-weight hyaluronan (HMWHA) improved cartilage repair. In the left image, injections with HMWHA alone produced less robust cartilage repair than the right image, where it was paired with P15-1. Credit: NYU Tandon School of Engineering Injuries of the knee resulting in...
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Home-Based Phototherapy for Psoriasis as Effective as Office-Based Treatment
TOPLINE: Home-based phototherapy for plaque and guttate psoriasis is as effective as office-based phototherapy, according to results of the randomized Light Treatment Effectiveness study. METHODOLOGY: TAKEAWAY: IN PRACTICE: “These data support the use of home phototherapy as a first-line treatment option for psoriasis,” and “efforts are needed to make home and office phototherapy more available to patients,”...
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Vitamin B12 Identified as a potential therapeutic agent in the prevention and treatment of acute pancreatitis
Acute pancreatitis (AP), which affects people of all ages, is one of the leading causes of hospital admission due to gastrointestinal diseases. Approximately 20% of patients develop moderate or severe acute pancreatitis, which carries extremely high mortality and disability rates. Even for those who recover, lifelong complications often follow, significantly affecting their quality of life....
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Multiple sclerosis trial suggests medication and cognitive behavioral therapy can reduce fatigue
Credit: Liza Summer from Pexels In a study of commonly used treatments for people with multiple sclerosis, both medical and behavioral interventions, and a combination of the two, resulted in meaningful improvements in fatigue, a University of Michigan-led study finds. The randomized clinical trial compared the effectiveness of modafinil, a wake-promoting medication used to treat sleepiness in...
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Novel procedure may bridge the treatment gap for symptomatic flexible flatfoot
A SESA screw stabilizing a patient’s foot and preventing bones from returning to a flat position. Credit: Children’s Hospital Boston Most children develop arches in their feet by early adolescence. About 20 percent, however, have pes planovalgus (PPV), also known as flexible flatfoot. Most children with PPV can participate in sports and other activities without...
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Atopic Dermatitis Control on Biologic Persists Over 3 Years
AMSTERDAM, Netherlands — For patients with atopic dermatitis (AD) who responded to the anti-interleukin (IL)-13 monoclonal antibody lebrikizumab in the pivotal trials, the level of response, including 90% skin clearance, has generally remained unchanged among those followed up for an additional 2 years, according to the latest data from an extension study. At the end...
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Brain cell connectivity research provides a potential target for anxiety disorders
Synopsis. Credit: The EMBO Journal (2024). DOI: 10.1038/s44318-024-00252-9 Scientists at Université de Montréal and its affiliated Montreal Clinical Research Institute (IRCM) have uncovered unique roles for a protein complex in the structural organization and function of brain cell connectivity, as well as in specific cognitive behaviors. The work by a team led by Hideto Takahashi, director of...