Gallstone disease shown to be strong predictor of pancreatic cancer

by American Gastroenterological Association

Pancreatic cancer cells (blue) growing as a sphere encased in membranes (red). Credit: National Cancer Institute

Patients with pancreatic ductal adenocarcinoma (PDAC) were six times more likely to have had gallstone disease within the year prior to diagnosis than non-cancer patients, suggesting gallstones could be a warning sign for this aggressive and deadly cancer, according to research to be presented at Digestive Disease Week (DDW) 2022. PDAC is the most common pancreatic cancer, accounting for more than 90% of cases, and it is often fatal because it tends to be diagnosed in late stages.

“Pancreatic cancer can be difficult to diagnose and then chances of survival are slim. Our findings suggest that gallstone disease may be a way to better diagnose this type of cancer—meaning we could save more lives,” said Marianna Papageorge, MD, lead researcher on the study and research fellow at Boston Medical Center.

Using records in the SEER-Medicare database from 2008 to 2015, researchers identified 18,700 PDAC patients and compared them to an average of 99,287 patients per year from the same database. In the year before diagnosis, 4.7 percent of the PDAC patients had a diagnosis of gallstone disease and 1.6 percent had their gallbladders removed. Among the non-cancer patients, only 0.8 percent had gallstones and only 0.3 percent had their gallbladders removal.

“Gallstone disease does not cause pancreatic cancer but understanding its association with PDAC can help combat the high mortality rate with pancreatic cancer by providing the opportunity for earlier diagnosis and treatment,” Dr. Papageorge said.

Since many people have gallstones but do not develop pancreatic cancer, future research could look more closely at laboratory findings and imaging to see if there are specific factors related to gallbladder disease that could further distinguish which patients might have or develop pancreatic cancer, Papageorge said.

“It is such a terrible disease, and survival is so low,” Dr. Papageorge said. “People present at such advanced stages, so anything we can do to try to diagnose people earlier and make sure that they’re getting curative treatment is crucial. This might be a key to better understanding next steps in screening, management and earlier diagnosis.”