by Society for the Study of Addiction

Credit: Unsplash/CC0 Public Domain

Cannabis use causes cellular damage that increases the risk of highly cancerous tumors, according to a paper published in Addiction Biology. The paper describes cannabis as a “genotoxic” substance because it damages a cell’s genetic information, which can lead to DNA mutations, accelerated aging, and cancer.

ADVERTISING

To make matters worse, this genotoxicity may be transmitted via damaged egg and sperm to the cannabis user’s offspring, making the risk of cannabis use trans-generational.

In a publication in Addiction Biology researchers from The University of Western Australia have made a link between established knowledge that cannabis use damages cellular energy production by inhibiting mitochondria and new cancer research published in Science showing that mitochondrial dysfunction drives chromosomal damage, which shows up as increased rates of cancer, accelerated aging, and birth defects.

The Science studies were not conducted in the context of cannabis use; however, they provide mechanistic insights into some observations about cannabis use that were not previously well understood, such as that cannabis causes both mitochondrial and genetic damage.

Taken together, the article in Addiction Biology puts older historical research about cannabis into context and suggests that cannabis-related genotoxic damage may be all around us—even if we largely don’t see it.

Co-author Dr. Stuart Reece comments, “The link we’ve described between cannabis use and genotoxicity has far-reaching consequences. This new research shows how genetic damage from cannabis use can be passed down the generations. This should reframe the discussion surrounding cannabis legalization from a personal choice to one that potentially involves multiple subsequent generations.”

More information: Albert Stuart Reece et al, Key insights into cannabis‐cancer pathobiology and genotoxicity, Addiction Biology (2024). DOI: 10.1111/adb.70003

Journal information:Addiction Biology , Science

Provided by Society for the Study of Addiction

---

Explore further

Recreational cannabis legalization tied to higher prenatal use