By WILLIAM COLE FOR MAILONLINE
PUBLISHED: 06:19 EDT, 31 May 2021 | UPDATED: 15:30 EDT, 31 May 2021
Researchers have successfully tested a new drug which can kill cancer cells without damaging nearby healthy tissue – removing the need for chemotherapy.
Scientists at the University of Edinburgh combined the tiny cancer-killing molecule called SeNBD with a chemical food to trick the harmful cells into ingesting it.
Cancerous cells are ‘greedy’ and need to consume high amounts of food for energy and they typically ingest more than healthy cells, the experts said.
By coupling SeNBD with a chemical food compound it becomes the ‘ideal prey for harmful cells’ which ingest it ‘without being alerted to its toxic nature’.
The drug was invented by University of Edinburgh researchers who compared it to a ‘Trojan Horse’, and its effects to a ‘metabolic warhead’.
The experimental study was carried out on zebrafish and human cells, but researchers say more studies are needed to confirm if it is a safe and swift method of treating early stage cancer and drug-resistant bacteria.
Scientists hope the treatment will boost survival rates among cancer patients and spare many from damaging chemotherapy.
So far, it has only been used on glioblastoma, the most common brain cancer.
SeNBD is also a light-activated photosensitiser, meaning it kills cells only after it is turned on by visible light.
This means a surgeon can precisely decide when they want to activate the drug, reducing the chances of it destroying healthy tissues and avoiding side-effects like hair loss caused by other anti-cancer agents, said the university.
The findings are published in the journal Nature Communications.
Lead researcher Professor Marc Vendrell, chair of translational chemistry and Biomedical Imaging at the University of Edinburgh, said: ‘This research represents an important advance in the design of new therapies that can be simply activated by light irradiation, which is generally very safe.
Researchers have successfully tested a new drug which can kill cancer cells without damaging nearby healthy tissue – removing the need for chemotherapy
‘SeNBD is one of the smallest photosensitisers ever made and its use as a “Trojan horse” opens many new opportunities in interventional medicine for killing harmful cells without affecting surrounding healthy tissue.’
Dr Sam Benson, a post-doctoral researcher at the university, said the mechanism of the drug’s delivery means it is delivered through the ‘front door of the cell’ rather than having to ‘find a way to batter through the cell’s defences’.
The legend of the Trojan Horse in Greek mythology recounts the tale of Greek soldiers constructing a giant hollowed-out wooden horse in which they hid to gain access to the city of Troy, having pretended to desert the war.
The Trojans took the massive structure as a gift and ushered it inside the city walls, only for Greek warriors to emerge from inside and sack the city.
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