by Zhang Nannan, Chinese Academy of Sciences Fig.1. Schematic summary of the exacerbated α-syn neuropathology in heterozygous familial PD. Credit: SIOC Amyloid deposition of α-synuclein (α-syn) is a hallmark of Parkinson’s disease (PD). α-Syn fibrillation and cell-to-cell transmission in the brain play an essential role in disease progression. To date, eight single-point mutations of SNCA have...
