Written by Stacia Woodcock, PharmD | Reviewed by Alyssa Billingsley, PharmDUpdated on October 28, 2022 Key takeaways: If you’re feeling fatigued, it’s possible your medication is the cause. For example, medications like fluoxetine (Prozac) and propranolol (Inderal) can make you feel tired. In some cases, drowsiness will go away over time as your body adjusts to the...