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Acetate controls endothelial-to-mesenchymal transition: Potential therapeutic target for reducing atherosclerosis
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Acetate controls endothelial-to-mesenchymal transition: Potential therapeutic target for reducing atherosclerosis

by Yale School of Medicine In a new study, researchers including Yale School of Medicine’s Michael Simons, MD, identify the molecular underpinnings of persistent endothelial-to-mesenchymal transition (EndMT), an important process related to vascular inflammation in diseases including pulmonary hypertension. Researchers found atypical acetate production from glucose triggered metabolic modulation of the endothelium activated TGF-β signaling, triggering a...