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Achilles’ heel spotted for promising HIV
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Achilles’ heel spotted for promising HIV

Amy Maxmen People wait to be seen at a clinic in Johannesburg, South Africa, that offers HIV drugs to treat or prevent infection.Credit: Foto24/Gallo Images/Getty An injectable drug that was lauded one year ago for being able to prevent HIV looks less perfect today, in light of a new analysis. Researchers revisited a 4,570-person clinical trial...

The Achilles’ heel of cancer stem cells
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The Achilles’ heel of cancer stem cells

MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE IN THE HELMHOLTZ ASSOCIATION IMAGE: EXPANDING CANCER STEM CELLS (GREEN) IN A COLON TUMOR WITH AN ONCOGENIC ACTIVATED WNT/BETA-CATENIN SIGNALING PATHWAY (RED). CREDIT: BIRCHMER LAB, MDC Since colonoscopies were introduced in Germany for early cancer detection, the number of diagnoses of advanced cancer every year has decreased, as precancerous...

Researchers pursue a vaccine to target an Achilles’ heel of the coronavirus
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Researchers pursue a vaccine to target an Achilles’ heel of the coronavirus

by Colorado State University Propelled by the COVID-19 pandemic, a Colorado State University research team is pursuing a vaccine that would thwart the novel coronavirus using a genetically modified form of the well-known probiotic Lactobacillus acidophilus, a bacterium commonly ingested in yogurt and other foods for gut health. The beneficial bacterium thrives exactly where the...

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Blood cancer’s Achilles’ heel opens door for new treatments

UNIVERSITY OF EDINBURGH New findings about a fatal form of blood cancer could aid the development of new drugs with significantly less harmful side effects than existing chemotherapy. The discovery could lead to novel treatments that efficiently eliminate blood cancer cells in acute myeloid leukaemia (AML), without harming healthy blood cells. Researchers have discovered how a protein in the body plays a key role in AML...