by Goethe University Frankfurt am Main Graphical abstract. Credit: iScience (2023). DOI: 10.1016/j.isci.2023.107844Leukemia is the most common type of cancer in children. Treatment involves intensive chemotherapy, which has severe side effects due to its non-specific mode of action. A team from the Department of Pediatrics and the Institute for Experimental Pediatric Hematology and Oncology at...
by Kyoto University Credit: iScience (2023). DOI: 10.1016/j.isci.2023.106081 When our bodies become infected, various immune responses are triggered, starting with a release of granulocytes, white blood cells containing special enzymes that make up about half or more of all human white blood cells. Neutrophils are also granulocytes that fight off invasive bacteria and fungi, often with zero...
by American Society for Biochemistry and Molecular Biology Graphical abstract. Credit: Molecular & Cellular Proteomics (2023). DOI: 10.1016/j.mcpro.2023.100503 A team of researchers has discovered a potential therapeutic that can synergize with existing drugs to more effectively kill certain leukemia cells. The authors published their results in Molecular & Cellular Proteomics. Acute myeloid leukemia is a cancer of developing immune cells. It can manifest...
by Universität Münster UB-modified lysines reside in functional domains of the IAV polymerase. a, b 3D structural models of a WSN-adapted heterotrimeric IAV polymerase bound to vRNA (adapted from PDB: 4WSB; a) or cRNA (adapted from PDB: 5EPI; b) created by comparative homology modeling. Positions of lysines with diglycyl remnants are depicted in violet (PB2,...
by Allessandra Dicorato, Broad Institute of MIT and Harvard Ovarian cancer cells overexpress high levels of the phosphate importer protein SLC34A2 (red) which pumps phosphate into a cell and leaves it vulnerable to inhibiting phosphate export. Cell nuclei are shown in blue. Credit : Daniel Bondeson Although the outlook for people with some types of cancers...
GOETHE UNIVERSITY FRANKFURT IMAGE: RESEMBLES A BUTTERFLY: ONLY IN ITS DIMER FORM DOES THE MANNITOL-SYNTHESIZING ENZYME OF THE HOSPITAL PATHOGEN ACINETOBACTER BAUMANNII PROTECT THE BACTERIUM FROM WATER LOSS AND DESICCATION. CREDIT: KLAAS MARTINUS POS, GOETHE UNIVERSITY FRANKFURT FRANKFURT. Each year, over 670,000 people in Europe fall ill through pathogenic bacteria that are resistant to antibiotics,...
WASHINGTON STATE UNIVERSITY One viral protein could provide information to deter pneumonia causing the body’s exaggerated inflammatory response to respiratory viruses, including the virus that causes COVID-19. That viral protein is NS2 of Respiratory Syncytial Virus (RSV), and a study has found that if the virus lacks this protein, the human body’s immune response can...
by Garvan Institute of Medical Research Graphical abstract. Credit: DOI: 10.1016/j.celrep.2021.109689 For breast cancer patients, standard-of care therapies become drastically less effective if their tumor has spread to other parts of the body, such as the lung. But a new treatment approach, investigated by a team at the Garvan Institute of Medical Research in experimental models, may help stop breast...
by Study Finds VANCOUVER, British Columbia — Scientists may be one step closer to defeating cancer after finding what researchers at the University of British Columbia call the disease’s “Achilles’ heel.” Their study has uncovered a protein that fuels tumors when oxygen levels are low. It enables the cancerous growths to adapt and survive and become more aggressive....
By Jocelyn Solis-Moreira Mar 29 2021 Have scientists uncovered the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Achilles’ heel? New preclinical research published in the journal Cell shows how neutralizing antibodies targeting the N-terminal domain of the coronavirus could be a potential target for antibodies to bind and effectively neutralize SARS-CoV-2. Study: N-terminal domain antigenic mapping reveals a site of vulnerability for...
