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Losing Muscle with GLP-1 RAs? There May be a Drug for That

NEW ORLEANS — Medications in development would preserve muscle mass and augment fat loss when used in combination with glucagon-like peptide 1 (GLP-1) receptor agonists taken for weight loss. As drugs such as semaglutide (Wegovy) and the dual agonist glucose-dependent insulinotropic polypeptide (GIP)/GLP-1 tirzepatide (Zepbound) are producing unprecedented degrees of weight loss in increasing numbers...

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How motor neurons develop into subtypes that activate different muscles

Motor neurons innervate the body; a study describes how a gene called Kdm6b helps these cells diversify into crucial subtypes. Motor neurons play a vital role in movement, linking the central nervous system with different muscles in the body. As such, scientists are very interested in understanding the biological mechanisms that control how these neurons form....