by Anja Lapac, Technical University Munich Cells similar to memory precursor T cells and to exhausted precursors exist early in acute infection. Credit: Nature (2025). DOI: 10.1038/s41586-024-08451-4 Even in the case of uncomplicated infections, the body prepares itself early on for the possibility of a more severe course. A research team from the Technical University of Munich (TUM)...
Tag: <span>Activation of immune T cells</span>
Post
How cancer hijacks the immune system by draining T cells’ energy
by Amsterdam University Medical Centers Credit: CC0 Public Domain Research into immunotherapy against cancer typically focuses on better recognition of cancer cells by the body’s own immune system. Researchers at Amsterdam UMC and Moffitt Cancer Center have taken a different approach. They investigated how cancer affects the energy management of a patient’s T cells and showed...
Post
The rules of immunity: What decides T cell fate?
by Stacy Kish, Yale University KLF2 prevents aberrant CD8 T cell differentiation in acute LCMV infection. Credit: Science (2025). DOI: 10.1126/science.adn2337 T cells are positioned at the frontline of the body’s immune system to fight infection, cancer, and autoimmune disease. While different subtypes of T cells exist, how these cells take their different forms has remained elusive. Now,...
Post
CAR-T cells can arm bystander T cells with CAR molecules via trogocytosis
Peer-Reviewed Publication Uppsala University FacebookXLinkedInWeChatBlueskyMessageWhatsAppEmail image: Postdoctoral position at Department of Immunology, Genetics and Pathology, Uppsala Universityview more Credit: Mikael Wallerstedt Engineered immune cells called CAR-T cells are used in the treatment of cancer. Researchers from Uppsala University have now discovered that CAR molecules can be transferred from the CAR-T cells to other T cells in...
Post
Lab-grown T cells with altered metabolism offer lasting cancer defense
by University of Pittsburgh A T cell killing a cancer cell. Credit: Andrew Frisch and Donna Stolz, University of Pittsburgh Center for Biologic Imaging Researchers from the University of Pittsburgh have developed a new way to grow T cells in the lab that enables them to live longer and better destroy cancer cells in a mouse...
Post
Scientists uncover how cancer cells hijack T-cells, making it harder for the body to fight back
by Justin Jackson , Medical Xpress mtDNA-mutated mitochondria from cancer cells transfer to TILs and are progressively replaced to homoplasmy in TILs. Credit: Nature (2025). DOI: 10.1038/s41586-024-08439-0 Research led by the Chiba Cancer Center Research Institute in Japan has discovered a surprising way cancer evades the immune system. It essentially hacks the immune cells, transferring its own...
Post
T cells’ capability to fully prevent acute viral infections opens new avenues for vaccine development
T cells can independently prevent acute viral infections to an extent previously thought only possible with neutralising antibodies.Peer-Reviewed Publication Duke-NUS Medical School image: Clusters of T cells, that are part of our immune system protecting us against harmful pathogens, under a microscope. By studying them, Duke-NUS scientists have found that T cells can independently control acute viral infections to...
Post
Engineered T cells could help patients overcome resistance to CAR T cell therapy
by City of Hope National Medical Center Engineering a leucine zipper-based cell-sorting system. Credit: Nature Biomedical Engineering (2024). DOI: 10.1038/s41551-024-01287-3 Physician-researchers with City of Hope have developed a way to add features to T cells to help them overcome mechanisms of chimeric antigen receptor (CAR) T cell therapy resistance. Their new system is outlined in a paper published in Nature Biomedical...
Post
Bayesian metamodeling provides insight into how T cells are activated
by Hebrew University of Jerusalem Overview: Integration of multiple molecular mechanisms is needed to qualitatively explain nanoscale TCR activation patterns at early contacts. Credit: Frontiers in Immunology (2024). DOI: 10.3389/fimmu.2024.1412221 A research team behind a new study at the Hebrew University of Jerusalem has made an important breakthrough in understanding how immune cells known as T cells are...
Post
Immune cells reprogrammed to kill HIV-infected T cells
There exists a group of HIV-positive people who have the rare ability to naturally control the HIV infection. Now, after years of research, a team of scientists from the Institut Pasteur in Paris, has successfully reprogrammed cells that lack this ability, giving them the same incredible, antiviral potency. Less than one percent of people living...
- 1
- 2