by University of Miami Leonard M. Miller School of Medicine Acute myelocytic leukemia (AML). Credit: Unsplash/CC0 Public Domain The treatment landscape for acute myeloid leukemia (AML) is evolving rapidly, as research discoveries at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine and other academic cancer centers advance new, more effective therapies...
by Sanford Burnham Prebys Medical Discovery Institute Bone marrow aspirate showing acute myeloid leukemia. Several blasts have Auer rods. Credit: Wikipedia A new study led by scientists at Sanford Burnham Prebys has shown that the protein RNF5 plays an unusual role in acute myeloid leukemia (AML). Unlike its expected role, marking aberrant proteins for destruction, RNF5...
IMPACT JOURNALS LLC IMAGE: LC-MS/MS analysis identifies putative MNK1/2 targets and interactors. (A) FLAG-MNK2 or FLAG-MNK1 was overexpressed in 293T cells. MNK1/2 was immunoprecipitated from 293T cell lysates using anti-FLAG-M2 agarose conjugated beads. An empty vector was used as a negative control. Immunoprecipitated proteins were resolved by SDS-PAGE, and were prepared using standard techniques and...
WEILL CORNELL MEDICINE IMAGE: BLOOD SMEAR UNDER MICROSCOPY SHOWING ADULT ACUTE MYELOID LEUKEMIA. CREDIT: WCM Patients with acute myeloid leukemia (AML), the most common form of acute leukemia in adults, that has gone into remission following initial chemotherapy remain in remission longer and have improved overall survival when they are given a pill form of...
Apollomics, Inc., an innovative biopharmaceutical company committed to the discovery and development of mono- and combination- oncology therapies, and GlycoMimetics (Nasdaq: GLYC), announced APL-106 (uproleselan) has been granted Breakthrough Therapy Designation (BTD) from the China National Medical Products Administration (NMPA) Center for Drug Evaluation (CDE) for the treatment of relapsed/refractory acute myeloid leukemia (AML). Bone...
by Cincinnati Children’s Hospital Medical Center This genetic “heat map” shows that several key genes associated with cell proliferation become more active in mice bred to lack the mTOR gene. This activity helps build signaling pathways that can allow cancerous cells to avoid disruption from mTOR inhibitors, according to a study in PNAS led by experts...
by Andrea Greif, Leukemia & Lymphoma Society Bone marrow aspirate showing acute myeloid leukemia. Several blasts have Auer rods. Patients participating in The Leukemia & Lymphoma Society’s (LLS) groundbreaking precision medicine Beat AML Master Clinical Trial had superior outcomes compared to acute myeloid leukemia (AML) patients who opted for standard chemotherapy treatment, according to findings...
