Tag: <span>adeno-associated viruses (AAVs)</span>

Home / adeno-associated viruses (AAVs)
Toxicity of dorsal root ganglia is widely associated with CNS AAV gene therapy
Post

Toxicity of dorsal root ganglia is widely associated with CNS AAV gene therapy

MARY ANN LIEBERT, INC./GENETIC ENGINEERING NEWS JOURNAL IN THE FIELD AND PROVIDES ALL-INCLUSIVE ACCESS TO THE CRITICAL PILLARS OF HUMAN GENE THERAPY: RESEARCH, METHODS, AND CLINICAL APPLICATIONS New Rochelle, NY, September 2, 2020—A meta-analysis of non-human primate (NHP) studies showed that adeno-associated virus (AAV) gene therapy often caused dorsal root ganglion (DRG) pathology. There were...

Post

Regulatory and Exhausted T Cell Responses to AAV Capsid

Recombinant adeno-associated viruses (AAVs) are quickly becoming the preferred viral vector for viral gene delivery for the treatment of a wide variety of genetic disorders. However, since their use in a clinical trial targeting hemophilia B patients 10 years ago, immune responses to the AAV capsid appear to have hampered some of the early clinical...