Reviewed by Emily Henderson, B.Sc. An extensive international study led by Prof. Illana Gozes of Tel Aviv University’s Department of Human Molecular Genetics and Biochemistry found deposits of the tau protein typically found in Alzheimer’s patients in tissues taken from the postmortem brain of a 7-year-old autistic child. The child suffered from the ADNP syndrome,...
Tag: <span>ADNP</span>
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Artificial intelligence jump starts clinical trial for rare genetic disease
by Bob Shepard, University of Alabama at Birmingham It was a pretty simple e-mail. Just a couple of lines. “It looks like low-dose ketamine is an up-regulator for ADNP. Do you think this makes sense for ADNP patients?” Matt Might sent that e-mail to Matt Davis on Feb. 18, 2019. Might is the director of...
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Drug candidate may recover vocal abilities lost to ADNP syndrome
Protein snippet normalizes disrupted neural connectivity caused by genetic disorder, Tel Aviv University researchers say AMERICAN FRIENDS OF TEL AVIV UNIVERSITY Activity-dependent neuroprotective protein syndrome (ADNP syndrome) is a rare genetic condition that causes developmental delays, intellectual disability and autism spectrum disorder symptoms in thousands of children worldwide. There is no known remedy for the disorder. A...
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Drug candidate stabilizes essential transport mechanism in nerve cells
NAP blocks formation of ‘tangles’ that contribute to Alzheimer’s disease Tau is a key brain protein involved in Alzheimer’s disease and other brain diseases. Aggregates of Tau known as “neurofibrillary tangles” have been associated with nerve cell death and cognitive decline. An important new Tel Aviv University study published in Molecular Psychiatry pinpoints the mechanism harnessed by...