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Scientists discover gene mutation that signals aggressive melanoma
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Scientists discover gene mutation that signals aggressive melanoma

by The Mount Sinai Hospital Graphical abstract. Credit: Cell Reports (2022). DOI: 10.1016/j.celrep.2022.110637 Mutation of a gene called ARID2 plays a role in increasing the chance that melanoma, a deadly skin cancer, will turn dangerously metastatic, Mount Sinai researchers report. The findings suggest that patients whose melanoma tumors have an ARID2 mutation may have a more aggressive cancer and may need...

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Aggressive melanoma: Circular RNA explains spread

Researchers have zoomed in on the fine molecular and epigenetic mechanisms that explain the aggressive spread of melanoma. Scientists examine the epigenetic silencing of circRNA and how this drives the spread of melanoma. Along with DNA and proteins, RNA is one of the three essential macromolecules necessary for all forms of life. The typical process...