Simultaneous deletion of tetraspanins CD9/CD81 in mice progressively exhibits a variety of accelerating aging phenotypes such as cataracts, osteoporosis, emphysema, skin atrophy, muscle atrophy, and shorter survival. Chronic obstructive pulmonary disease (COPD) is an inflammatory disease that causes obstructed airflow, and it is expected to be the third leading cause of death globally by 2030....
Tag: <span>Aging</span>
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Decade by decade, aging presents common challenges
For 93-year-old Joseph Brown, the clearest sign of aging was his inability one day to remember he had to have his pants unzipped to pull them on. For 95-year-old Caroline Mayer, it was deciding at age 80 to put away her skis, after two hip replacements. And for 56-year-old Dr. Thomas Gill, a geriatrics professor...
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Cell stress response sheds light on treating inflammation-related cancer, aging
In response to irradiation, normal mice (left) show massive hair graying, while mice deficient in triggering inflammation (right) do not show gray hair. Stress — defined broadly — can have a profoundly deleterious effect on the human body. Even individual cells have their own way of dealing with environmental strains such as ultraviolet radiation from...
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Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging
Highlights A modified FOXO4-p53 interfering peptide causes p53 nuclear exclusion in senescent cells This FOXO4 peptide induces targeted apoptosis of senescent cells (TASC) TASC neutralizes murine liver chemotoxicity from doxorubicin treatment TASC restores fitness, hair density, and renal function in fast and naturally aged mice Summary The accumulation of irreparable cellular damage restricts healthspan after...
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UCLA biologists slow aging, extend lifespan of fruit flies
‘Cellular time machine’ could eventually benefit humans, too Nature Communications/Anil RanaFruit flies’ mitochondria (in green) at 10 days (top left), 28 days (top right) and 37 days old (both bottom images). At bottom right, the mitochondria have returned to a more youthful state after UCLA biologists increased the fly’s level of a protein called Drp1....
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Researchers review the clinical potential of senolytic drugs on aging
Researchers are moving closer to realizing the clinical potential of drugs that have previously been shown to support healthy aging in animals. In a review article published online in the Journal of the American Geriatrics Society, Mayo Clinic aging experts say that, if proven to be effective and safe in humans, these drugs could be “transformative”...
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Reaction time variation may be a marker that predicts mortality in old age
A common indicator of neurobiological disturbance among the elderly may also be associated with mortality, according to a study published August 9, 2017 in the open access journal PLOS ONE by Nicole A. Kochan at the Centre for Healthy Brain Ageing (CHeBA), UNSW Sydney. Intraindividual reaction time variability (IIVRT), defined as an individual’s variation in reaction times...
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Preparing for longevity—we don’t need to become frail as we age
Age-related frailty may be a treatable and preventable health problem, just like obesity, diabetes, and cardiovascular disease, highlights a review in Frontiers in Physiology. “Societies are not aware of frailty as an avoidable health problem and most people usually resign themselves to this condition,” says Jerzy Sacha, Head of the Catheterization Laboratory at the University Hospital in Opole,...
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Cell aging in lung epithelial cells
Pulmonary fibrosis can possibly be attributed to a kind of cellular aging process, which is called senescence. This has been shown by researchers from the Helmholtz Zentrum München, partner in the German Center for Lung Research (DZL). As they report in the European Respiratory Journal, they have already successfully counteracted this mechanism in the cell culture...
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Lutein may counter cognitive aging, study finds
Spinach and kale are favorites of those looking to stay physically fit, but they also could keep consumers cognitively fit, according to a new study from University of Illinois researchers. The study, which included 60 adults aged 25 to 45, found that middle-aged participants with higher levels of lutein – a nutrient found in green...