by Brandie Jefferson, Washington University in St. Louis “Older adults might be representing events in different ways, and transitions might be picked up differently than, say, a 20-year-old,” said Zachariah Reagh, assistant professor of psychological and brain sciences in Arts & Sciences. Reagh looked at fMRI images to study memory differences in different age groups. Credit:...
Senescent cells accumulate with age, but are never more than a tiny fraction of somatic cells in most tissues, even in very late life. Senescent cells nonetheless cause considerable harm via the signals that they produce, the senescence-associated secretory phenotype (SASP). These signals provoke chronic inflammation, harmful remodeling of tissue, and dysfunctional activity in nearby cells. That comparatively few senescent cells...
By Nick Lavars Young stem cells (left) produce more material (dark brown) for bone than old stem cells (center), and a new study shows how they can be rejuvenated by adding sodium acetate (right)Pouikli/Max Planck Institute for Biology of AgeingVIEW 1 IMAGES Scientists looking into the biological mechanisms behind deteriorating bones have made a discovery...
BUCK INSTITUTE FOR RESEARCH ON AGING IMAGE: THESE C. ELEGANS HAVE BEEN EXPOSED TO MITOCHONDRIAL STRESS THAT INDUCE PROTEIN MISFOLDING IN THEIR MITOCHONDRIA, WHICH ACTIVATES A GFP REPORTER THROUGHOUT THE BODY OF THE WORM. CREDIT: SUZANNE ANGELI, PHD, BUCK INSTITUTE FOR RESEARCH ON AGING Every cell in the body goes through thousands of chemical reactions...
IMAGE: STRUCTURAL EQUATION MODELS FOR EXECUTIVE FUNCTIONS AND MOTOR PERFORMANCE IN OLDER ADULTS. (A) STRUCTURAL EQUATION MODEL FOR CORRELATED FACTORS OF INHIBITION, SHIFTING, AND UPDATING. UPDATING SIGNIFICANTLY PREDICTS PERFORMANCE ON THE COMPLEX CONDITION OF THE BIMANUAL COORDINATION TASK IN OLDER ADULTS. (B) STRUCTURAL EQUATION MODEL WITH ORTHOGONAL FACTORS, ACCOUNTING FOR VARIANCE SHARED BY ALL NEUROPSYCHOLOGICAL...
IMAGE: CALYCOSIN INHIBITED BREAST CANCER CELLS GROWTH IN VIVO. (A, B) CALYCOSIN INHIBITED SUBCUTANEOUS TUMORIGENESIS USING NUDE MICS MODELS. (C) TUMORS VOLUME CURVES OVER TIME. (D) THE AVERAGE WEIGHT OF TUMORS. THE DATA WERE REPRESENTED AS MEANS ± SD. *P<0.05; **P<0.01. CREDIT: YUZHONG ZHENG AND FENGLIAN YANG Aging-US published “Calycosin inhibits breast cancer cell migration and...
IMAGE: STRUCTURAL EQUATION MODELS FOR EXECUTIVE FUNCTIONS AND MOTOR PERFORMANCE IN OLDER ADULTS. (A) STRUCTURAL EQUATION MODEL FOR CORRELATED FACTORS OF INHIBITION, SHIFTING, AND UPDATING. UPDATING SIGNIFICANTLY PREDICTS PERFORMANCE ON THE COMPLEX CONDITION OF THE BIMANUAL COORDINATION TASK IN OLDER ADULTS. (B) STRUCTURAL EQUATION MODEL WITH ORTHOGONAL FACTORS, ACCOUNTING FOR VARIANCE SHARED BY ALL NEUROPSYCHOLOGICAL...
WASHINGTON — It’s long been believed that advancing age leads to broad declines in our mental abilities. Now new research from Georgetown University Medical Center offers surprisingly good news by countering this view. The findings, published August 19, 2021, in Nature Human Behaviour, show that two key brain functions, which allow us to attend to new information and to...
by Washington State University A double-stranded DNA fragment. Credit: Vcpmartin/Wikimedia/ CC BY-SA 4.0 The human body is essentially made up of trillions of living cells. It ages as its cells age, which happens when those cells eventually stop replicating and dividing. Scientists have long known that genes influence how cells age and how long humans live,...
Ferroptosis is a mode of programmed cell death that manages to be both fairly well explored in the broader research community and far less visible than other programmed cell death processes. It was first named and described a decade ago, though of course researchers have long explored aspects of its biochemistry. There is some thought...
