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Key mechanisms of airway relaxation in asthma revealed in new study

UNIVERSITY HOSPITALS CLEVELAND MEDICAL CENTER CLEVELAND–Many therapeutics for asthma and other obstructive lung diseases target the β2-adrenergic receptor (β2AR), a G protein-coupled receptor (GPCR) that rapidly supports airway relaxation when stimulated. Yet, overuse of these agents is associated with adverse health outcomes, including death, which has limited their utility as frontline therapies.   Now, a...