by Emily Leclerc, University of Wisconsin-Madison A hallmark of Alexander disease is the buildup of abnormal proteins called Rosenthal fibers, pictured here (red) in brain tissue from a study of a rat model of the disease. The study identified a potential treatment and helped provide early data for a human clinical trial now underway. Credit: Tracy...
by Huntsman Cancer Institute To visualize LEM2’s role in mitosis, the Ullman Lab used colored fluorescent markers to label the different components: LEM2, the fibers, and the DNA. Credit: Huntsman Cancer Institute To replace aging and worn cells, the body primarily uses a process called mitosis, in which one cell divides into two. When a...
by University of North Carolina Health Care Immunofluorescence staining of Alexander Disease iPSC-astrocytes showing cell nuclei (white), cytoplasmic GFAP filaments (magenta), and perinuclear GFAP aggregates (green; marked by yellow arrowheads). Credit: Lab of Natasha Snider, PhD, UNC School of Medicine Scientists have known that genetic mutations leading to the production of a defective protein called GFAP...
