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Researchers reveal a new ALS hallmark, shedding light on a likely trigger of neurodegeneration
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Researchers reveal a new ALS hallmark, shedding light on a likely trigger of neurodegeneration

by  King’s College London PreT-IR transcripts undergo cleavage/polyadenylation and neurite localisation in SFPQ-deprived neurons. a Correlation between RNAseq read slope gradient in null and number of cleavage sites in introns of sloping IR-transcripts. Two-tailed Pearson correlation coefficient, r: −0.3506, p < 0.0001 (n = 247 sloping IR-transcripts, FDR < 0.05). b Efficiency of cleavage site usage in classic (Left; (n = 107, FDR < 0.05)) and sloping (Middle; (n = 37, m < −0.1, FDR < 0.05)) IR-transcripts...