by UK Research and Innovation The newly discovered structure of clumped TDP-43, from the brains of people with ALS. Credit: B. Ryskeldi-Falcon/MRC Laboratory of Molecular Biology Scientists have determined for the first time the structure of the molecule associated with amyotrophic lateral sclerosis (ALS) and multiple other neurodegenerative diseases. The scientists at the Medical Research...
UNIVERSIDAD COMPLUTENSE DE MADRID UCC-UCM, 8 November 2021. Amyotrophic lateral sclerosis (ALS), characterised by harm to brain neurons and to the spinal cord, also affects the tissue of the retina, according to a study headed up by Universidad Complutense de Madrid (UCM). The research, published in Neural Regeneration Research, indicates that patients with ALS may suffer changes in...
by Niigata University Demethylation of DNA in the TDP-43 autoregulatory region using dCas9-TET1 fusion system attenuates alternative splicing involved in autoregulation and increases TDP-43 gene expression. Credit: Niigata University Amyotrophic lateral sclerosis (ALS) is an intractable neurological disease. Aging is a risk factor for the accumulation of TDP-43 (transduction responsive region DNA-binding protein of 43kDa)...
by Karolinska Institutet An MRI with increased signal in the posterior part of the internal capsule which can be tracked to the motor cortex consistent with the diagnosis of ALS. Credit: Frank Gaillard/Wikipedia The causes of the serious muscle disease ALS still remain unknown. Now, researchers at Karolinska Institutet and KTH Royal Institute of Technology, among others, have...
SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI IMAGE: THE SCIENTISTS DEVELOPED AN EXPERIMENTAL TECHNIQUE ABLE TO DETECT THE PROTEIN TDP-43 EVEN WHEN IT IS PRESENT IN THE BODY IN MINUTE QUANTITIES AND IN THE EARLIER STAGES OF DISEASE. A test to diagnose two very serious diseases such as ALS and FTD when the pathologies have not...
by American Academy of Neurology Children and teens with family members with amyotrophic lateral sclerosis, or ALS, help with bathing, dressing, eating and all types of caregiving activities, yet they may not have training or enough information about the disease, according to a study published in the March 18, 2020, online issue of Neurology, the...
Researchers at Karolinska Institutet in Sweden and the University of Milan in Italy have identified a gene in human neurons that protects against the degeneration of motor neurons in the deadly diseases ALS and SMA. Gene therapy in animal models of these diseases was shown to protect against cell death and increase life expectancy. The...
by Mikayla MacE, University of Arizona A therapeutic intervention for amyotrophic lateral sclerosis, better known as ALS or Lou Gehrig’s disease, could be on the horizon thanks to unexpected findings by University of Arizona researchers. ALS is the progressive degeneration of motor neurons that causes people to lose the ability to move and eventually speak,...
by Karolinska Institutet Patients with ALS (amyotrophic lateral sclerosis) often suffer from type 2 diabetes. This phenomenon has long remained mechanistically enigmatic. Now, researchers at Karolinska Institutet in Sweden have identified a molecular mechanism linking these two diseases. The study is published in the scientific journal PNAS. The researchers found that immunoglobulin G (IgG) antibodies...
Powerhouses of the cell ‘eat themselves up,’ jumpstart path to neurodegenerative disease NORTHWESTERN UNIVERSITY CHICAGO — Northwestern Medicine scientists have discovered a new phenomenon in the brain that could explain the development of early stages of neurodegeneration that is seen in diseases such as ALS, which affects voluntary muscle movement such as walking and talking....
