by Karolinska Institutet Credit: Pixabay/CC0 Public Domain Mechanisms associated with a particular diabetes drug can also help to protect against Alzheimer’s disease, a study by researchers at Karolinska Institutet in Sweden and published in Neurology reports. The results indicate that the drug’s target protein could be an interesting candidate for the treatment of Alzheimer’s disease. Alzheimer’s disease...
by NYU Langone Health Three images, as seen by fluorescent microscopy, show flower-like formations (at decreasing resolution) of autophagic vacuoles in neurons of Alzheimer’s disease mouse. Credit: Springer-Nature Publishing. A breakdown in how brain cells rid themselves of waste precedes the buildup of debris-filled plaques known to occur in Alzheimer’s disease, a new study in...
by Johns Hopkins University School of Medicine The same glycoform of RPTPζ carries CD33 and Siglec-8 ligands. A, equal aliquots of human cerebral cortex total protein extract from four donors (numbered) were resolved on replicate composite agarose–acrylamide gels and blotted to PVDF. One blot (upper panels) was double-label probed with CD33-Fc (red) and anti-RPTPζ (green)...
The accumulation of amyloid-beta and tau proteins in the brain is linked to Alzheimer’s disease, and now research shows that such accumulation can disrupt connections between brain structures important for memory. The new study, led by investigators at Harvard Medical School and Massachusetts General Hospital and published in PNAS, revealed that these disrupted connections were present years before...
UNIVERSITY OF KANSAS IMAGE: IN A SERIES OF TESTS, KU RESEARCHERS ASSESSED THE MEMORY OF INJECTED MICE AGAINST SIMILAR MICE THAT DIDN’T RECEIVE THE CORN-BASED METHIONINE SULFOXIDE. CREDIT: SMITH, ET AL. LAWRENCE — During experiments in animal models, researchers at the University of Kansas have discovered a possible new approach to immunization against Alzheimer’s disease (AD)....
About 11% of the U.S. population 65 and older has been diagnosed with Alzheimer’s disease (AD), the most common form of dementia that results in memory loss and cognitive impairment, according to the Alzheimer’s Association. And the World Health Organization predicts the number of people living with Alzheimer’s will grow by millions each year. Despite...
INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) Identifying genetic risk factors for Alzheimer’s disease is essential if we are to improve our understanding and treatment of it. Progress in human genome analysis along with genome-wide association studies[ are now leading to major advances in the field. Researchers in Europe, the US and...
by Chinese Academy of Sciences Neuronal C/EBPβ escalation shortens the life span of mice, leading to neural excitation. Credit: SIAT Cognitive decline during normal aging is exacerbated in neurodegenerative disease including Alzheimer’s disease (AD). While it is not yet known exactly what causes AD, there are a number of risk factors that make a person...
BOSTON UNIVERSITY SCHOOL OF MEDICINE (BOSTON) – Living your best life at 35, ignoring cholesterol and glucose levels, may impact your chances of getting Alzheimer’s disease (AD) later in life. According to researchers from Boston University School of Medicine (BUSM), lower HDL (high-density cholesterol) and high triglyceride levels measured in blood as early as age...
Reviewed by Emily Henderson, B.Sc. Mar 18 2022 An international group of researchers led by the UAB analyzed the genes that are expressed in neurons and astrocytes based on data from 800 individuals and compared what happens in Alzheimer’s patients and in people without diagnosed dementia. The study, published in Neurobiology of disease, highlights the...
