BARCELONA INSTITUTE FOR GLOBAL HEALTH (ISGLOBAL) Investigators from the Barcelonaβeta Brain Research Center (BBRC), the research arm of the Pasqual Maragall Foundation, in collaboration with ISGlobal, have found an association between exposure to air pollution and higher levels of biomarkers of Alzheimer’s disease, particularly in individuals with elevated beta-amyloid deposition in the brain. The results...
Tag: <span>Alzheimer’s disease</span>
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“Supermeres” may carry clues to cancer, Alzheimer’s disease and COVID-19
IMAGE: CUTLINE: MEMBERS OF THE SUPERMERE DISCOVERY TEAM INCLUDE (FRONT ROW FROM LEFT) QI LIU, PHD, ROBERT COFFEY, MD, QIN ZHANG, PHD, AND (BACK ROW FROM LEFT) JAMES HIGGINBOTHAM, PHD; DENNIS JEPPESEN, PHD; AND JEFFREY FRANKLIN, PHD. (PHOTO BY ERIN O. SMITH) CREDIT: VANDERBILT UNIVERSITY MEDICAL CENTER Researchers at Vanderbilt University Medical Center have discovered...
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Cleveland Clinic research identifies sildenafil as candidate drug for Alzheimer’s disease
CLEVELAND CLINIC IMAGE: ACCORDING TO FINDINGS PUBLISHED IN NATURE AGING, THE RESEARCH TEAM, LED BY FEIXIONG CHENG, PH.D., OF CLEVELAND CLINIC’S GENOMIC MEDICINE INSTITUTE, DETERMINED THAT SILDENAFIL IS ASSOCIATED WITH 69% REDUCED INCIDENCE OF ALZHEIMER’S DISEASE. CREDIT: CLEVELAND CLINIC December 6, 2021, CLEVELAND: A new Cleveland Clinic-led study has identified sildenafil – an FDA-approved therapy for erectile...
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Targeting the brain’s immune cells may help prevent or treat Alzheimer’s disease
by Weill Cornell Medical College Single cell RNA-seq analysis of microglial response in a mouse model of Alzheimer’s disease. Treatment with experimental drug MK2206 depleted a subcluster of disease-associated microglia (pink) and protected against synaptic loss (not pictured). Each dot depicts one microglial cell. Different colors depict different microglial states. Credit: Dr. Li Gan. A...
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Dental device for snoring may slow onset of Alzheimer’s disease
by Center for BrainHealth This figure shows changes in cognitive assessment scores for individuals in each group (CN=cognitively normal, MCI=mild cognitive impairment, AD=Alzheimer’s disease) at the start of the study and after 4 weeks. Credit: Center for BrainHealth A good night’s sleep plays an essential role in regulating brain health by removing the waste material...
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Potential new treatment for Alzheimer’s disease would be relatively cheap
RIKEN IMAGE: NEPRILYSIN (RED) AND AΒ (GREEN) LEVELS IN THE HIPPOCAMPUS OF ALZHEIMER’S DISEASE MODEL MICE. TOP: CONTROL. BOTTOM: AFTER BEING FED DIAZOXIDE. AFTER DIAZOXIDE TREATMENT, NEPRILYSIN LEVELS INCREASED AND AΒ LEVELS DECREASES. MICE ALSO PERFORMED BETTER ON MEMORY TESTS (NOT SHOWN HERE). CREDIT: RIKEN Researchers at the RIKEN Center for Brain Science (CBS) in...
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Bench-to-bedside drug design could lead to new Alzheimer’s disease treatments
by University of Glasgow Credit: CC0 Public Domain An international team of scientists and pharmaceutical collaborators has made a breakthrough “bench to bedside” discovery, ten years in the making, which they hope will advance the future treatment of Alzheimer’s disease in patients. The research—conducted at the University of Glasgow and the biotechnology company Sosei-Heptares Ltd...
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New framework for analyzing Alzheimer’s disease identifies not one form, but three
by University of Geneva Fig. 1: The probabilistic model of Alzheimer disease. Credit: DOI: 10.1038/s41583-021-00533-w According to the commonly accepted model, Alzheimer’s disease is characterized by an ineluctable sequence, from the accumulation of toxic proteins in the brain to dementia resulting from neurodegeneration. While this deterministic sequence is sometimes true, it does not seem to be...
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Drug designed for Alzheimer’s disease may hold promise for treating glioblastoma
by Cleveland Clinic Glioblastoma (histology slide). Credit: Wikipedia/CC BY-SA 3.0 New Cleveland Clinic research has found that drugs originally designed to help treat Alzheimer’s disease may hold promise for glioblastoma, the most common and lethal type of primary brain tumor. The findings were published in Nature Cancer. A class of drugs called BACE1 inhibitors were once among...
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Mutant mice breakthrough finds probable cause of Alzheimer’s disease
by Thomas Crow, Particle The numbers of Australians with dementia are increasing each year (largely because of population growth). Credit: Australian Institute of Health and Welfare A team of WA researchers may have discovered a cheap, revolutionary treatment for Alzheimer’s disease—and the key is a body part you may not expect. Dementia is the second leading...