by University of Helsinki Credit: Pixabay/CC0 Public Domain A study conducted at the University of Helsinki and the Helsinki University Hospital (HUS) suggests that the APOE4 allele may also increase cerebral microhaemorrhages related to COVID-19 and associate with mental fatigue related to long COVID. Roughly one-third of Finns carry the APOE4 allele, a genetic variant that...
Tag: <span>Alzheimer’s disease</span>
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Is energy the key to Alzheimer’s disease?
by University of Adelaide Credit: Pixabay/Pete Linforth. A team of researchers at the University of Adelaide has found a link between the way that cells produce energy for brain function and the mutated genes found in Alzheimer’s disease. The discovery published in Disease Models and Mechanisms has prompted further examination of the link as a fundamental, early...
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Greater exposure to nitrogen dioxide linked to higher levels of biomarkers of Alzheimer’s disease in the brain
BARCELONA INSTITUTE FOR GLOBAL HEALTH (ISGLOBAL) Investigators from the Barcelonaβeta Brain Research Center (BBRC), the research arm of the Pasqual Maragall Foundation, in collaboration with ISGlobal, have found an association between exposure to air pollution and higher levels of biomarkers of Alzheimer’s disease, particularly in individuals with elevated beta-amyloid deposition in the brain. The results...
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“Supermeres” may carry clues to cancer, Alzheimer’s disease and COVID-19
IMAGE: CUTLINE: MEMBERS OF THE SUPERMERE DISCOVERY TEAM INCLUDE (FRONT ROW FROM LEFT) QI LIU, PHD, ROBERT COFFEY, MD, QIN ZHANG, PHD, AND (BACK ROW FROM LEFT) JAMES HIGGINBOTHAM, PHD; DENNIS JEPPESEN, PHD; AND JEFFREY FRANKLIN, PHD. (PHOTO BY ERIN O. SMITH) CREDIT: VANDERBILT UNIVERSITY MEDICAL CENTER Researchers at Vanderbilt University Medical Center have discovered...
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Cleveland Clinic research identifies sildenafil as candidate drug for Alzheimer’s disease
CLEVELAND CLINIC IMAGE: ACCORDING TO FINDINGS PUBLISHED IN NATURE AGING, THE RESEARCH TEAM, LED BY FEIXIONG CHENG, PH.D., OF CLEVELAND CLINIC’S GENOMIC MEDICINE INSTITUTE, DETERMINED THAT SILDENAFIL IS ASSOCIATED WITH 69% REDUCED INCIDENCE OF ALZHEIMER’S DISEASE. CREDIT: CLEVELAND CLINIC December 6, 2021, CLEVELAND: A new Cleveland Clinic-led study has identified sildenafil – an FDA-approved therapy for erectile...
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Targeting the brain’s immune cells may help prevent or treat Alzheimer’s disease
by Weill Cornell Medical College Single cell RNA-seq analysis of microglial response in a mouse model of Alzheimer’s disease. Treatment with experimental drug MK2206 depleted a subcluster of disease-associated microglia (pink) and protected against synaptic loss (not pictured). Each dot depicts one microglial cell. Different colors depict different microglial states. Credit: Dr. Li Gan. A...
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Dental device for snoring may slow onset of Alzheimer’s disease
by Center for BrainHealth This figure shows changes in cognitive assessment scores for individuals in each group (CN=cognitively normal, MCI=mild cognitive impairment, AD=Alzheimer’s disease) at the start of the study and after 4 weeks. Credit: Center for BrainHealth A good night’s sleep plays an essential role in regulating brain health by removing the waste material...
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Potential new treatment for Alzheimer’s disease would be relatively cheap
RIKEN IMAGE: NEPRILYSIN (RED) AND AΒ (GREEN) LEVELS IN THE HIPPOCAMPUS OF ALZHEIMER’S DISEASE MODEL MICE. TOP: CONTROL. BOTTOM: AFTER BEING FED DIAZOXIDE. AFTER DIAZOXIDE TREATMENT, NEPRILYSIN LEVELS INCREASED AND AΒ LEVELS DECREASES. MICE ALSO PERFORMED BETTER ON MEMORY TESTS (NOT SHOWN HERE). CREDIT: RIKEN Researchers at the RIKEN Center for Brain Science (CBS) in...
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Bench-to-bedside drug design could lead to new Alzheimer’s disease treatments
by University of Glasgow Credit: CC0 Public Domain An international team of scientists and pharmaceutical collaborators has made a breakthrough “bench to bedside” discovery, ten years in the making, which they hope will advance the future treatment of Alzheimer’s disease in patients. The research—conducted at the University of Glasgow and the biotechnology company Sosei-Heptares Ltd...
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New framework for analyzing Alzheimer’s disease identifies not one form, but three
by University of Geneva Fig. 1: The probabilistic model of Alzheimer disease. Credit: DOI: 10.1038/s41583-021-00533-w According to the commonly accepted model, Alzheimer’s disease is characterized by an ineluctable sequence, from the accumulation of toxic proteins in the brain to dementia resulting from neurodegeneration. While this deterministic sequence is sometimes true, it does not seem to be...