by UT Southwestern Medical Center Electrical Current Models During HD-tDCS. Credit: The Journal of Prevention of Alzheimer’s Disease (2025). DOI: 10.1016/j.tjpad.2024.100023 Repeated sessions of electrical stimulation to brain networks associated with memory improved verbal learning in some Alzheimer’s disease patients for up to eight weeks in a preliminary trial led by UT Southwestern Medical Center researchers. The findings, published in The Journal...
Tag: <span>Alzheimer’s disease</span>
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Alzheimer’s treatment may lie in the brain’s own cleanup crew: Harnessing microglia to clear plaques
by Northwestern University A spatial transcriptomics machine holds brain tissue samples in David Gate’s lab in Chicago. Credit: Northwestern University For more than three decades, scientists have been racing to stop Alzheimer’s disease by removing amyloid beta plaques—sticky clumps of toxic protein that accumulate in the brain. Now, a new Northwestern Medicine study suggests a promising...
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Key form of tau protein identified for understanding and treating Alzheimer’s disease
by Eva Schissler, University of Cologne Knockout of tau causes mild deficits in neurite growth and AIS formation but does not alter neuronal activity. Credit: Alzheimer’s & Dementia (2025). DOI: 10.1002/alz.14403, https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/alz.14403 A research team at the University of Cologne has made a significant breakthrough in understanding the role of the tau protein in Alzheimer’s disease. Using human induced...
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Down syndrome case challenges Alzheimer’s assumptions with unexpected cognitive stability
by Anna Ligorio, University of Pittsburgh Credit: University of Pittsburgh Studies reveal that people with Down syndrome (DS) have over a 90% lifetime risk of developing dementia caused by Alzheimer’s disease (AD) as they age. Research from the University of Pittsburgh’s Swanson School of Engineering aims could uncover why some people with DS develop dementia while others do not— providing...
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How air pollution and wildfire smoke may contribute to memory loss in Alzheimer’s disease
by The Scripps Research Institute Brain cells (green) derived from people with Alzheimer’s disease (center) show far fewer projections than healthy neurons (left). Blocking S-nitrosylation of CRTC1, however, restores the cells to a healthier state (right). Credit: Scripps Research Air pollution contributes to nearly 7 million premature deaths each year, and its effects go far beyond...
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New study raises alarm over Alzheimer’s blood tests
by Andrew Smith, Rutgers University Performance and correlates of the automated plasma p-Tau217 assay. Credit: Alzheimer’s & Dementia (2025). DOI: 10.1002/alz.14585. https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.14585 Research from Rutgers Health indicates that blood tests for Alzheimer’s disease need to be interpreted with caution—particularly for Black patients. “These tests are currently geared towards primary care physicians and directly to older adults concerned about cognitive performance,” said William Hu, director...
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Alzheimer’s brain inflammation: Immune cells react differently to amyloid-beta, research suggests
by Biophysical Society Myddosome formation (shown in yellow-green) is triggered by Aβ aggregates (shown in red) in macrophages. Credit: Arpan Dey. Brain inflammation, while a crucial part of the body’s immune response, takes on a detrimental role in Alzheimer’s disease. Unlike the acute, short-lived inflammation that combats infection, the inflammation associated with Alzheimer’s becomes chronic and...
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Next-gen Alzheimer’s drugs extend independent living by months
by Washington University in St. Louis Credit: Unsplash/CC0 Public Domain In the past two years, the Food and Drug Administration has approved two novel Alzheimer’s therapies, based on data from clinical trials showing that both drugs slowed the progression of the disease. But while the approvals of lecanemab and donanemab, both antibody therapies that clear plaque-causing...
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How a former navy mechanic defied the genetic odds of inherited Alzheimer’s disease
by Justin Jackson , Medical Xpress Schematic representation of the pedigree for the DIAN family carriers of the pathogenic mutation PSEN2 p.Asn141Ile. Credit: Nature Medicine (2025). DOI: 10.1038/s41591-025-03494-0 Researchers at Washington University School of Medicine in St. Louis have conducted a longitudinal study on an individual carrying the presenilin 2 (PSEN2) p.Asn141Ile mutation, a genetic variant known...
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Lab-designed chimeric protein shows beneficial effects in animal models of Alzheimer’s disease
by Autonomous University of Barcelona Credit: Autonomous University of Barcelona A research team at the Institut de Neurociències of the Universitat Autònoma de Barcelona (INc-UAB) has developed a new protein capable of improving memory and reducing tau protein levels in animal models of Alzheimer’s disease. The new compound—HEBE, generated by fusing three proteins—represents a new approach...