by Mayo Clinic Credit: Unsplash/CC0 Public Domain In a new paper published in Nature Communications, Mayo Clinic researchers and collaborators report the protein-coding gene SERPINA5 may worsen tau protein tangles, which are characteristic of Alzheimer’s disease, and advance disease. By combining clinical expertise, brain tissue samples, pathology expertise and artificial intelligence, the team clarified and validated the relevance of...
INSTITUTE OF PHYSICAL CHEMISTRY OF THE POLISH ACADEMY OF SCIENCES IMAGE: NEURONS CREATE A UNIQUE NETWORK THAT IS DAMAGED WHEN AFFECTED BY ALZHEIMER’S DISEASE. CREDIT: SOURCE: IPC PAS, GRZEGORZ KRZYZEWSKI Alzheimer’s disease (AD) is a form of progressive dementia interfering with daily living. It is caused by the decline in the number of brain cells...
THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE PHOENIX, Ariz. — April 13, 2021 — Findings of a study by the Translational Genomics Research Institute (TGen), an affiliate of City of Hope, suggest that increasing expression of a gene known as ABCC1 could not only reduce the deposition of a hard plaque in the brain that leads to Alzheimer’s disease, but might...
by University of Tokyo Credit: Unsplash/CC0 Public Domain A small, light-activated molecule recently tested in mice represents a new approach to eliminating clumps of amyloid protein found in the brains of Alzheimer’s disease patients. If perfected in humans, the technique could be used as an alternative approach to immunotherapy and used to treat other diseases caused...
by Public Library of Science This image shows the close relationship between phospholipase D3 and the pathological hallmarks of Alzheimer’s disease in tissue from the temporal lobe of a human brain. Phospholipase D3, which is primarily in neurons, is shown in green and neuritic plaques and neurofibrillary tangles are in red stained with thiazine red. Credit:...
MASSACHUSETTS GENERAL HOSPITAL BOSTON – Researchers have used a genetic engineering strategy to dramatically reduce levels of tau–a key protein that accumulates and becomes tangled in the brain during the development of Alzheimer’s disease–in an animal model of the condition. The results, which come from investigators at Massachusetts General Hospital (MGH) and Sangamo Therapeutics Inc., could lead...
by University of Southampton Credit: Unsplash/CC0 Public Domain Newly published research has revealed a close link between proteins associated with Alzheimer’s disease and age-related sight loss. The findings could open the way to new treatments for patients with deteriorating vision and through this study, the scientists believe they could reduce the need for using animals in future research into blinding...
CENTER FOR GENOMIC REGULATION IMAGE: MIREIA SEUMA (LEFT), FIRST AUTHOR OF THE STUDY AND RESEARCHER AT IBEC NEXT TO BENEDETTA BOLOGNESI (RIGHT), ONE OF THE LEAD AUTHORS OF THE STUDY AND JUNIOR GROUP LEADER AT IBEC. CREDIT: THE INSTITUTE FOR BIOENGINEERING OF CATALONIA, IBEC A study published in the journal eLife made all the possible mutations in...
MASSACHUSETTS GENERAL HOSPITAL BOSTON – New treatments for Alzheimer’s disease are desperately needed, but numerous clinical trials of investigational drugs have failed to generate promising options. Now a team at Massachusetts General Hospital (MGH) and Harvard Medical School (HMS) has developed an artificial intelligence-based method to screen currently available medications as possible treatments for Alzheimer’s...
ROCKEFELLER UNIVERSITY PRESS IMAGE: Compared with a control (left), treatment with the novel GSM (right) reduces the number of amyloid plaques (green) and proinflammatory cells called microglia (magenta) in the brains of mice carrying mutations linked to early-onset Alzheimer’s disease. CREDIT: ©2021 RYNEARSON ET AL. ORIGINALLY PUBLISHED IN JOURNAL OF EXPERIMENTAL MEDICINE. HTTPS://DOI.ORG/10.1084/JEM.20202560 Researchers at the University of...
