Researchers at University of California San Diego School of Medicine have launched a first-in-human Phase I clinical trial to assess the safety and efficacy of a gene therapy to deliver a key protein into the brains of persons with Alzheimer’s disease (AD) or Mild Cognitive Impairment (MCI), a condition that often precedes full-blown dementia. The protein,...
by IOS Press Credit: Pixabay/CC0 Public Domain Early diagnosis of Alzheimer’s disease has been shown to reduce cost and improve patient outcomes, but current diagnostic approaches can be invasive and costly. A recent study, published in the Journal of Alzheimer’s Disease, has found a novel way to identify a high potential for developing Alzheimer’s disease before symptoms...
MASSACHUSETTS GENERAL HOSPITAL IMAGE: By mapping individuals’ unique brain anatomy, Massachusetts General Hospital researchers have identified early tau PET imaging signals to track Alzheimer’s pathology. Left: Tau PET images for a person with normal cognition. Right: top, 3D brain surface rendering with tau PET overlay; bottom, flat map showing brain surface details, with cortical tau...
by New York University The compound ISRIB shrank plaques in the brain in a mouse model of Alzheimer’s disease (right, rectangle). Credit: M.M. Oliveira et al., Science Signaling (2021) A team of neuroscientists has identified a potential means to address the loss of cognitive function due to Alzheimer’s disease by targeting protein synthesis in mice. Their...
by University of Queensland Credit: Dr. Juan Polanco et. al., The University of Queensland. University of Queensland researchers have discovered a new ‘seeding’ process in brain cells that could be a cause of dementia and Alzheimer’s disease. UQ’s Queensland Brain Institute dementia researcher Professor Jürgen Götz said the study revealed that tangled neurons, a hallmark sign of dementia,...
by University of Sheffield The brain with all the white matter tracts visible. White matter tracts are susceptible to damage in people with uncontrolled cardiovascular risks like obesity. Credit: The University of Sheffield New research from the University of Sheffield has found being overweight is an additional burden on brain health and it may exacerbate Alzheimer’s disease. The...
INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUE – INRS IMAGE: INRS PROFESSOR CHARLES RAMASSAMY, SPECIALIST ON ALZHEIMER’S DISEASE, DOCTORAL STUDENT MOHAMED RAÂFET BEN KHEDHER AND POSTDOCTORAL STUDENT MOHAMED HADDAD. CREDIT: INRS A Quebec research team has discovered two early plasma markers to detect Alzheimer’s disease five years before its onset. The results of this recent study led by...
IOS PRESS IMAGE: UNIDAD DE DETERIORO COGNITIVO CREDIT: VALDECILLA Amsterdam, January 21, 2021 – A new study published in the Journal of Alzheimer’s Disease carried out by researchers at the Marqués de Valdecilla-IDIVAL University Hospital, in collaboration with researchers at the University of Bonn Medical Center, proposes that major surgery is a promoter or accelerator of Alzheimer’s disease (AD). The...
UNIVERSITY OF CAMBRIDGE Researchers from the University of Cambridge, the University of Milan and Google Research have used machine learning techniques to predict how proteins, particularly those implicated in neurological diseases, completely change their shapes in a matter of microseconds. They found that when amyloid beta, a key protein implicated in Alzheimer’s disease, adopts a highly disordered shape,...
by American Academy of Neurology Credit: Unsplash/CC0 Public Domain Primary progressive aphasia is a rare neurodegenerative condition characterized by prominent language problems that worsen over time. About 40% of people with the condition have underlying Alzheimer’s disease. But a new study has found that people with the condition may not develop the memory problems associated with...
