Tag: <span>Alzheimer’s disease</span>

Home / Alzheimer’s disease
A new mechanism of toxicity in Alzheimer’s disease revealed by the 3-D structure of protein
Post

A new mechanism of toxicity in Alzheimer’s disease revealed by the 3-D structure of protein

by Institute for Research in Biomedicine (IRB Barcelona) The amyloid precursor protein (APP) is inserted into the cell membrane of neurons. After sequential cleavage by β- and ?-secretases, the Aβ protein (in green) is released.The membrane oligomers are formed by 4 or 8 copies of the Aβ protein. The physicochemical properties of the edges of...

It’s not just Alzheimer’s disease: Research highlights form of dementia
Post

It’s not just Alzheimer’s disease: Research highlights form of dementia

by University of Kentucky The long-running study on aging and brain health at the University of Kentucky’s Sanders-Brown Center on Aging Alzheimer’s Disease Center has once again resulted in important new findings—highlighting a complex and under-recognized form of dementia. The work was recently published in the Journal of the American Medical Association (JAMA): Neurology. “One...

Repeated head impacts associated with later-life depression symptoms, worse cognitive function
Post

Repeated head impacts associated with later-life depression symptoms, worse cognitive function

by Boston University School of Medicine Scientists have long believed that a single traumatic brain injury (TBI) earlier in life may contribute to problems with memory, thinking and depression later in life. In most previous studies, however, research failed to examine the possible role of having a history of exposure to repetitive head impacts, including...

How ApoE4 endangers the brain
Post

How ApoE4 endangers the brain

by Max Delbrück Center for Molecular Medicine Apolipoprotein E (ApoE) is kind of like a delivery service for the human brain. It supplies neurons with important nutrients, including with polyunsaturated fatty acids—which are building blocks of the membranes surrounding the neurons. In addition, certain unsaturated fatty acids are converted into so-called endocannabinoids. These are endogenous...

Different ‘subtypes’ of Alzheimer’s may be linked to different modifications of the tau protein
Post

Different ‘subtypes’ of Alzheimer’s may be linked to different modifications of the tau protein

by Massachusetts General Hospital A new study reveals a possible biological reason that Alzheimer’s Disease (AD) progresses at different rates in different patients. The study, which was led by Massachusetts General Hospital researchers, focused on tau, a protein found in the neurofibrillary tangles in the brain that are a well-known sign of AD. Tau can...

New indication of a link between Alzheimer’s and diabetes
Post

New indication of a link between Alzheimer’s and diabetes

by Forschungszentrum Juelich Pathological protein clumps are characteristic of a series of diseases, such as Alzheimer’s disease, Parkinson’s disease, and type 2 diabetes. Scientists at Forschungszentrum Jülich, Heinrich Heine University Düsseldorf, and Maastricht University have now used cryo-electron microscopy to obtain a sharp image for the first time of how individual molecules are arranged in...

Memory impairment in mice reduced by soy derivate that can enter the brain intact
Post

Memory impairment in mice reduced by soy derivate that can enter the brain intact

Ingestion of the protein fragment improved working and long-term memory in mice treated to simulate Alzheimer’s disease KYUSHU UNIVERSITY In a study that could help one day give a literal meaning to food for thought, researchers from Kyushu University in Japan have reported that a protein fragment that makes its way into the brain after...