Rockville, Md. (March 22, 2019)–A new article explores the pathophysiological factors that link sleep disturbances and Alzheimer’s disease. Better understanding of this connection may lead to potential diagnostics and therapeutics for Alzheimer’s disease and other neurodegenerative diseases and dementia. The article is published ahead of print in the Journal of Neurophysiology (JNP). Alzheimer’s research has largely focused on the presence...
Tag: <span>Alzheimer’s disease</span>
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A billion years of evolution suggests a new approach for Alzheimer’s disease treatment
by Royal Holloway, University of London Credit: CC0 Public Domain New research by academics at Royal Holloway, University of London, urges scientists that are looking to finding a cure for Alzheimer’s disease to focus on the role of proteins in the brain that cause Alzheimer’s disease. This change in focus could enable the development of new treatments. It...
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Is It Alzheimer’s Or Another Dementia? The Right Answer Matters
In the U.S., older people with dementia are usually told they have Alzheimer’s disease. But a range of other brain diseases can also impair thinking and memory and judgment, according to scientists attending a summit on dementias held Thursday and Friday at the National Institutes of Health. These include strokes, a form of Parkinson’s disease and a disease that damages brain...
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Women should not be alarmed by study linking HRT to Alzheimer’s disease
Doctors are encouraging women not to be alarmed by a new study linking the use of hormone replacement therapy (HRT) with a slightly increased risk of Alzheimer’s disease. The Royal College of GPs says the research does not prove that HRT causes Alzheimer’s disease and that women who are using the therapy should continue to do so. The study, which was recently published in...
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Data sharing uncovers five new risk genes for Alzheimer’s disease
Analysis of genetic data from more than 94,000 individuals has revealed five new risk genes for Alzheimer’s disease, and confirmed 20 known others. An international team of researchers also reports for the first time that mutations in genes specific to tau, a hallmark protein of Alzheimer’s disease, may play an earlier role in the development...
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Listening in to brain communications, without surgery
Plenty of legitimate science – plus a whole lot of science fiction – discusses ways to “hack the brain.” What that really means, most of the time – even in the fictional examples – involves surgery, opening the skull to implant wires or devices physically into the brain. But that’s difficult, dangerous and potentially deadly....
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Antiepileptic drugs linked to increased hospital stays in persons with Alzheimer’s disease
People with Alzheimer’s disease who used antiepileptic drugs had a higher number of accumulated hospital stays than people with Alzheimer’s disease who did not use antiepileptics, according to a new study from the University of Eastern Finland. The results were published in the Journal of American Medical Directors Association. During a two-year follow-up, persons who...
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Scientists have reversed memory loss in a mouse model of Alzheimer’s Disease
By focusing on the epigenetic changes that influence gene expression, scientists at the University of Buffalo have managed to reduce memory loss and improve cognitive function in a mouse model of Alzheimer’s disease. Sebastian Kaulitzki | Shutterstock For the study, the team studied mice with gene mutations for familial Alzheimer’s and analyzed post-mortem brain tissues...
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Bacterial pathogen Porphyromonas gingivalis may contribute to Alzheimer’s disease: Study
Cortexyme, Inc., a privately held, clinical-stage pharmaceutical company developing therapeutics to alter the course of Alzheimer’s disease (AD) and other degenerative disorders, today announced publication of a foundational paper supporting its approach in Science Advances. In the paper, an international team of researchers led by Cortexyme co-founders Stephen Dominy, M.D. and Casey Lynch detail the...
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Researchers answer decades-old question about protein found in Alzheimer’s brain plaques
Alzheimer’s-affected brains are riddled with so-called amyloid plaques: protein aggregates consisting mainly of amyloid-β. However, this amyloid-β is a fragment produced from a precursor protein whose normal function has remained enigmatic for decades. A team of scientists at VIB and KU Leuven led by professors Joris de Wit and Bart De Strooper has now uncovered that this amyloid precursor protein modulates neuronal signal...