By focusing on the epigenetic changes that influence gene expression, scientists at the University of Buffalo have managed to reduce memory loss and improve cognitive function in a mouse model of Alzheimer’s disease. Sebastian Kaulitzki | Shutterstock For the study, the team studied mice with gene mutations for familial Alzheimer’s and analyzed post-mortem brain tissues...
Tag: <span>Alzheimer’s disease</span>
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Bacterial pathogen Porphyromonas gingivalis may contribute to Alzheimer’s disease: Study
Cortexyme, Inc., a privately held, clinical-stage pharmaceutical company developing therapeutics to alter the course of Alzheimer’s disease (AD) and other degenerative disorders, today announced publication of a foundational paper supporting its approach in Science Advances. In the paper, an international team of researchers led by Cortexyme co-founders Stephen Dominy, M.D. and Casey Lynch detail the...
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Researchers answer decades-old question about protein found in Alzheimer’s brain plaques
Alzheimer’s-affected brains are riddled with so-called amyloid plaques: protein aggregates consisting mainly of amyloid-β. However, this amyloid-β is a fragment produced from a precursor protein whose normal function has remained enigmatic for decades. A team of scientists at VIB and KU Leuven led by professors Joris de Wit and Bart De Strooper has now uncovered that this amyloid precursor protein modulates neuronal signal...
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Could a drinkable drug cocktail reverse Alzheimer’s? Solution restored memories of mice and stopped the disease in its tracks
Tens of millions of people around the world suffer from Alzheimer’s Disease There is no cure, treatments are limited and more and more people are dying of the devastating brain disease Scientists at Yale University wanted to find a way to disrupt the early protein binding that leads to the disease They discovered that an old antibiotic in a...
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Alzheimer’s Disease and Gingko Biloba
What is Ginkgo Biloba? Ginkgo biloba is a tree that is native to China and has been used in traditional Chinese medicine and cuisine for centuries. Extracts of Ginkgo biloba are often sold as food supplements with potential medicinal uses ranging from treating high blood pressure to altitude sickness. The efficacy of Ginkgo extracts for...
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Wiring diagram of the brain provides a clearer picture of brain scan data
Already affecting more than five million Americans older than 65, Alzheimer’s disease is on the rise and expected to impact more than 13 million people by 2050. Over the last three decades, researchers have relied on Neuroimaging—brain scans such as magnetic resonance imaging (MRI) or positron emission tomography (PET) – to study Alzheimer’s disease and...
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New PET tracer identified for imaging tau in Alzheimer’s disease patients
Checkerboard plot showing 18F-RO-948-positivity results (black cells: bilaterally positive; gray cells: unilaterally positive) of anterior and posterior Braak regions (19), and estimated Braak stages (right column) (20). esV = extrastriatal …more In the diagnosis of Alzheimer’s disease and the search for effective treatments, tau tangles in the brain have joined amyloid build-up as markers of...
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Study points to novel epigenetic target for Alzheimer’s Disease
A research team at the University of Miami Miller School of Medicine’s Center for Therapeutic Innovation (CTI) has identified a novel epigenetic drug target to simultaneously normalize multiple deficits in Alzheimer’s disease (AD), the most common form of dementia in the elderly and the sixth leading cause of death in the U.S., according to the...
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Retiring Later May Be One Way to Lower Your Alzheimer’s Risk
Experts say continuing to work can keep you mentally sharp. So can exercise and engaging with family and friends. Image: Being at a job can challenge your brain and help lower your Alzheimer’s risk, experts say. Getty Images Crossword puzzles are fine, but you probably should be doing more to stimulate your brain to help...
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Scientists create new map of brain region linked to Alzheimer’s disease
Curing some of the most vexing diseases first requires navigating the world’s most complex structure—the human brain. So, USC scientists have created the most detailed atlas yet of the brain‘s memory bank. Cartographers of the cranium, a USC research team has illustrated the internal circuitry of the hippocampus in detail that would make the great...